Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality
Exposure to organophosphate esters (OPEs) is extensive, yet few studies have investigated their association with hormone levels or semen quality. Here, we studied the association between urinary concentrations of OPEs and their metabolites with hormone levels and semen parameters in men (n = 117) pr...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022003294 |
| _version_ | 1818109208928714752 |
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| author | Shabana Siddique Imen Farhat Cariton Kubwabo Peter Chan Cynthia G. Goodyer Bernard Robaire Jonathan Chevrier Barbara F. Hales |
| author_facet | Shabana Siddique Imen Farhat Cariton Kubwabo Peter Chan Cynthia G. Goodyer Bernard Robaire Jonathan Chevrier Barbara F. Hales |
| author_sort | Shabana Siddique |
| collection | DOAJ |
| description | Exposure to organophosphate esters (OPEs) is extensive, yet few studies have investigated their association with hormone levels or semen quality. Here, we studied the association between urinary concentrations of OPEs and their metabolites with hormone levels and semen parameters in men (n = 117) predominantly in the 20–29 years age range who were recruited from the greater Montreal area between 2009 and 2012. Urine, serum, and semen samples were analyzed for OPEs, hormones, and semen quality, respectively. Bis(2-ethylhexyl) phosphate (BEHP), bis(2,4-di-tert-butylphenyl) hydrogen phosphate (B2,4DtBPP), tris(2-chloroisopropyl) phosphate (TCIPP), diphenyl phosphate (DPHP), bis (2-butoxyethyl) phosphate (BBOEP) and di-cresyl phosphate (DCPs) were detected in urine at a frequency ≥ 95%. The highest geometric mean concentration was observed for DPHP (18.54 ng/mL) and the second highest was B2,4DtBPP (6.23 ng/mL). Associations between a doubling in analyte concentrations in urine and hormone levels and semen quality parameters were estimated using multivariable linear regression. B2,4DtBPP levels were positively associated with total T3 (β = 0.09; 95% CI: 0.01, 0.17). DPHP was inversely associated with estradiol (β = -2.56; 95% CI: −5.00, −0.17), and TCIPP was inversely associated with testosterone (β = -0.78; 95% CI: −1.40, −0.17). Concentrations of BCIPP were inversely associated with sperm concentrations (β = -7.76; 95% CI: −14.40, −0.61), progressive motility (β = − 4.98; 95% CI: −8.71, −1.09), and the sperm motility index (β = -9.72; 95% CI: −17.71, −0.96). In contrast, urinary DPHP concentrations were positively associated with the sperm motility (β = 4.37; 95% CI: 0.76, 8.12) and fertility indices (β = 6.64; 95% CI: 1.96, 11.53). Thus, OPE detection rates were high and exposure to several OPEs was associated with altered hormone levels and semen parameters. The possibility that OPEs affect male reproduction warrants further investigation. |
| first_indexed | 2024-12-11T02:27:36Z |
| format | Article |
| id | doaj.art-0090767105ab4bb2a4cec4c771e9111e |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-11T02:27:36Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-0090767105ab4bb2a4cec4c771e9111e2022-12-22T01:23:53ZengElsevierEnvironment International0160-41202022-08-01166107402Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen qualityShabana Siddique0Imen Farhat1Cariton Kubwabo2Peter Chan3Cynthia G. Goodyer4Bernard Robaire5Jonathan Chevrier6Barbara F. Hales7Exposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, CanadaDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, CanadaExposure and Biomonitoring Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, CanadaDivision of Urology, McGill University Health Centre, Montreal, QC, CanadaResearch Institute of McGill University Health Centre, Montreal, QC, Canada; Department of Pediatrics, McGill University, Montreal, QC, CanadaDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada; Department of Obstetrics and Gynecology, McGill University, Montreal, QC, CanadaDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, CanadaDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada; Corresponding author at: Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC H3G 1Y6, Canada.Exposure to organophosphate esters (OPEs) is extensive, yet few studies have investigated their association with hormone levels or semen quality. Here, we studied the association between urinary concentrations of OPEs and their metabolites with hormone levels and semen parameters in men (n = 117) predominantly in the 20–29 years age range who were recruited from the greater Montreal area between 2009 and 2012. Urine, serum, and semen samples were analyzed for OPEs, hormones, and semen quality, respectively. Bis(2-ethylhexyl) phosphate (BEHP), bis(2,4-di-tert-butylphenyl) hydrogen phosphate (B2,4DtBPP), tris(2-chloroisopropyl) phosphate (TCIPP), diphenyl phosphate (DPHP), bis (2-butoxyethyl) phosphate (BBOEP) and di-cresyl phosphate (DCPs) were detected in urine at a frequency ≥ 95%. The highest geometric mean concentration was observed for DPHP (18.54 ng/mL) and the second highest was B2,4DtBPP (6.23 ng/mL). Associations between a doubling in analyte concentrations in urine and hormone levels and semen quality parameters were estimated using multivariable linear regression. B2,4DtBPP levels were positively associated with total T3 (β = 0.09; 95% CI: 0.01, 0.17). DPHP was inversely associated with estradiol (β = -2.56; 95% CI: −5.00, −0.17), and TCIPP was inversely associated with testosterone (β = -0.78; 95% CI: −1.40, −0.17). Concentrations of BCIPP were inversely associated with sperm concentrations (β = -7.76; 95% CI: −14.40, −0.61), progressive motility (β = − 4.98; 95% CI: −8.71, −1.09), and the sperm motility index (β = -9.72; 95% CI: −17.71, −0.96). In contrast, urinary DPHP concentrations were positively associated with the sperm motility (β = 4.37; 95% CI: 0.76, 8.12) and fertility indices (β = 6.64; 95% CI: 1.96, 11.53). Thus, OPE detection rates were high and exposure to several OPEs was associated with altered hormone levels and semen parameters. The possibility that OPEs affect male reproduction warrants further investigation.http://www.sciencedirect.com/science/article/pii/S0160412022003294Organophosphate estersSemen qualityHormonesEndocrine disrupting chemicals |
| spellingShingle | Shabana Siddique Imen Farhat Cariton Kubwabo Peter Chan Cynthia G. Goodyer Bernard Robaire Jonathan Chevrier Barbara F. Hales Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality Environment International Organophosphate esters Semen quality Hormones Endocrine disrupting chemicals |
| title | Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality |
| title_full | Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality |
| title_fullStr | Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality |
| title_full_unstemmed | Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality |
| title_short | Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality |
| title_sort | exposure of men living in the greater montreal area to organophosphate esters association with hormonal balance and semen quality |
| topic | Organophosphate esters Semen quality Hormones Endocrine disrupting chemicals |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022003294 |
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