The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing inflammation. Immune cells including macrophages, lymphocyt...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/4/309 |
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| author | Sebastian Makuch Kamil Więcek Marta Woźniak |
| author_facet | Sebastian Makuch Kamil Więcek Marta Woźniak |
| author_sort | Sebastian Makuch |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing inflammation. Immune cells including macrophages, lymphocytes, neutrophils, mast cells, natural killer cells, innate lymphoid cells, as well as synovial tissue cells, like fibroblast-like synoviocytes, chondrocytes, and osteoclasts secrete different proinflammatory factors, including many cytokines, angiogenesis-stimulating molecules and others. Recent studies reveal that curcumin, a natural dietary anti-inflammatory compound, can modulate the response of the cells engaging in RA course. This review comprises detailed data about the pathogenesis and inflammation process in rheumatoid arthritis and demonstrates scientific investigations about the molecular interactions between curcumin and immune cells responsible for rheumatoid arthritis development to discuss this herbal drug’s immunoregulatory role in RA treatment. |
| first_indexed | 2024-03-10T12:43:06Z |
| format | Article |
| id | doaj.art-00912bcc46fb4bccb5bcae48e42f70a7 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T12:43:06Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-00912bcc46fb4bccb5bcae48e42f70a72023-11-21T13:42:21ZengMDPI AGPharmaceuticals1424-82472021-04-0114430910.3390/ph14040309The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid ArthritisSebastian Makuch0Kamil Więcek1Marta Woźniak2Department of Pathology, Wroclaw Medical University, 50-367 Wroclaw, PolandDepartment of Biotechnology, Wroclaw University, 50-383 Wroclaw, PolandDepartment of Pathology, Wroclaw Medical University, 50-367 Wroclaw, PolandRheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing inflammation. Immune cells including macrophages, lymphocytes, neutrophils, mast cells, natural killer cells, innate lymphoid cells, as well as synovial tissue cells, like fibroblast-like synoviocytes, chondrocytes, and osteoclasts secrete different proinflammatory factors, including many cytokines, angiogenesis-stimulating molecules and others. Recent studies reveal that curcumin, a natural dietary anti-inflammatory compound, can modulate the response of the cells engaging in RA course. This review comprises detailed data about the pathogenesis and inflammation process in rheumatoid arthritis and demonstrates scientific investigations about the molecular interactions between curcumin and immune cells responsible for rheumatoid arthritis development to discuss this herbal drug’s immunoregulatory role in RA treatment.https://www.mdpi.com/1424-8247/14/4/309rheumatoid arthritiscurcuminimmune cellsimmunomodulationautoimmune disease |
| spellingShingle | Sebastian Makuch Kamil Więcek Marta Woźniak The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis Pharmaceuticals rheumatoid arthritis curcumin immune cells immunomodulation autoimmune disease |
| title | The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis |
| title_full | The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis |
| title_fullStr | The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis |
| title_full_unstemmed | The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis |
| title_short | The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis |
| title_sort | immunomodulatory and anti inflammatory effect of curcumin on immune cell populations cytokines and in vivo models of rheumatoid arthritis |
| topic | rheumatoid arthritis curcumin immune cells immunomodulation autoimmune disease |
| url | https://www.mdpi.com/1424-8247/14/4/309 |
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