Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study
BackgroundBile acids (BAs) have been proposed to promote gastrointestinal cells carcinogenesis. However, studies on serum total bile acid (TBA) levels and gastrointestinal cancers (GICs) risk are rare.MethodsWe conducted a retrospective case–control study from 2015 to 2019 at the First Affiliated Ho...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.859716/full |
| _version_ | 1818219060190511104 |
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| author | Songbo Li Xiaodong Qu Luyao Zhang Na Wang Min Chen Xingyu Zhao Jie Wang Jie Wang Huanhuan Lv Huanhuan Lv Ying Qi Ying Qi Lifeng Zhang Junye Liu Yongquan Shi |
| author_facet | Songbo Li Xiaodong Qu Luyao Zhang Na Wang Min Chen Xingyu Zhao Jie Wang Jie Wang Huanhuan Lv Huanhuan Lv Ying Qi Ying Qi Lifeng Zhang Junye Liu Yongquan Shi |
| author_sort | Songbo Li |
| collection | DOAJ |
| description | BackgroundBile acids (BAs) have been proposed to promote gastrointestinal cells carcinogenesis. However, studies on serum total bile acid (TBA) levels and gastrointestinal cancers (GICs) risk are rare.MethodsWe conducted a retrospective case–control study from 2015 to 2019 at the First Affiliated Hospital of Air Force Military Medical University, in which 4,256 GICs cases and 1,333 controls were recruited. Patients’ demographic, clinical and laboratory data were collected. The odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using binary logistic regression models.ResultsPositive associations were observed between serum TBA levels and risks of esophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC). Overall, ORs of EC, GC and CRC risk rose with the TBA levels increasing. After adjustment for potential confounders, the OR of TBA-positive for EC risk was 4.89 (95% CI: 3.20-7.49), followed by GC (OR: 3.92, 95% CI: 2.53-6.08), and CRC (OR: 3.32, 95% CI: 2.04-5.11). Patients aged 60 years or older have a higher risk of GICs, especially for EC patients. Males are associated with a higher risk of GC, while females are associated with a higher risk of CRC. Preoperative serum TBA positive and negative was significantly different in the presence or absence of hematogenous metastasis among EC patients (P=0.014), and lymph node metastasis among GC patients (P=0.018).ConclusionsThis retrospective study showed positive associations between serum TBA level and GICs risk, and a higher serum TBA level constitutes a risk factor for GICs. |
| first_indexed | 2024-12-12T07:33:39Z |
| format | Article |
| id | doaj.art-00913059ac324bb5a2a2e2b9f6c56546 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T07:33:39Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-00913059ac324bb5a2a2e2b9f6c565462022-12-22T00:32:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.859716859716Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective StudySongbo Li0Xiaodong Qu1Luyao Zhang2Na Wang3Min Chen4Xingyu Zhao5Jie Wang6Jie Wang7Huanhuan Lv8Huanhuan Lv9Ying Qi10Ying Qi11Lifeng Zhang12Junye Liu13Yongquan Shi14State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaSchool of Clinical Medicine, Xi’an Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaSchool of Clinical Medicine, Xi’an Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaSchool of Clinical Medicine, Xi’an Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Radiation Protective Medicine, School of Military Preventive Medicine, Air Force Medical University, Xi’an, ChinaState Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi’an, ChinaBackgroundBile acids (BAs) have been proposed to promote gastrointestinal cells carcinogenesis. However, studies on serum total bile acid (TBA) levels and gastrointestinal cancers (GICs) risk are rare.MethodsWe conducted a retrospective case–control study from 2015 to 2019 at the First Affiliated Hospital of Air Force Military Medical University, in which 4,256 GICs cases and 1,333 controls were recruited. Patients’ demographic, clinical and laboratory data were collected. The odds ratios (ORs) with 95% confidence intervals (CIs) were estimated using binary logistic regression models.ResultsPositive associations were observed between serum TBA levels and risks of esophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC). Overall, ORs of EC, GC and CRC risk rose with the TBA levels increasing. After adjustment for potential confounders, the OR of TBA-positive for EC risk was 4.89 (95% CI: 3.20-7.49), followed by GC (OR: 3.92, 95% CI: 2.53-6.08), and CRC (OR: 3.32, 95% CI: 2.04-5.11). Patients aged 60 years or older have a higher risk of GICs, especially for EC patients. Males are associated with a higher risk of GC, while females are associated with a higher risk of CRC. Preoperative serum TBA positive and negative was significantly different in the presence or absence of hematogenous metastasis among EC patients (P=0.014), and lymph node metastasis among GC patients (P=0.018).ConclusionsThis retrospective study showed positive associations between serum TBA level and GICs risk, and a higher serum TBA level constitutes a risk factor for GICs.https://www.frontiersin.org/articles/10.3389/fonc.2022.859716/fullgastrointestinal cancer (GI cancer)serumbile acid (BA)biomarkersepidemiology - analytic (risk factors) |
| spellingShingle | Songbo Li Xiaodong Qu Luyao Zhang Na Wang Min Chen Xingyu Zhao Jie Wang Jie Wang Huanhuan Lv Huanhuan Lv Ying Qi Ying Qi Lifeng Zhang Junye Liu Yongquan Shi Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study Frontiers in Oncology gastrointestinal cancer (GI cancer) serum bile acid (BA) biomarkers epidemiology - analytic (risk factors) |
| title | Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study |
| title_full | Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study |
| title_fullStr | Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study |
| title_full_unstemmed | Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study |
| title_short | Serum Total Bile Acids in Relation to Gastrointestinal Cancer Risk: A Retrospective Study |
| title_sort | serum total bile acids in relation to gastrointestinal cancer risk a retrospective study |
| topic | gastrointestinal cancer (GI cancer) serum bile acid (BA) biomarkers epidemiology - analytic (risk factors) |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.859716/full |
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