Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension
AIM. To estimate the spread and distribution of genotypes and alleles of thrombosis predisposition gene polymorphisms in adolescents with essential hypertension (EH). MATERIALS AND METHODS. One hundred and thirty-seven 14- to 17-year-old adolescents were examined. There were 3 examined groups: 1) 37...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2014-09-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31552 |
| _version_ | 1818508363480170496 |
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| author | V V Dolgikh S E Bol'shakova L I Kolesnikova I M Mikhalevich |
| author_facet | V V Dolgikh S E Bol'shakova L I Kolesnikova I M Mikhalevich |
| author_sort | V V Dolgikh |
| collection | DOAJ |
| description | AIM. To estimate the spread and distribution of genotypes and alleles of thrombosis predisposition gene polymorphisms in adolescents with essential hypertension (EH). MATERIALS AND METHODS. One hundred and thirty-seven 14- to 17-year-old adolescents were examined. There were 3 examined groups: 1) 37 EH patients with prothrombotic changes (PTC); 2) 60 EH patients without PTC; 3) 40 healthy adolescents. Prothrombin time, activated partial thromboplastin time, and the levels of fibrinogen and soluble fibrin monomer complexes were determined. The adolescents were assigned to a PTC group if they had changes by one or several above indicators. Polymerase chain reaction assay was used to type coagulation factor II (FII) and factor V (FV), plasminogen activator inhibitor type 1 (PAI-1), 5,10-methylenetetrahydrofolate reductase (MTHFR), and methionine syntase reductase (MTRR) gene polymorphisms. Group differences were determined by qualitative signs, by using the χ2 test and Yates' correction for continuity and Fisher's exact test if one of the groups had at least 5 individuals. All differences were considered statistically significant at p |
| first_indexed | 2024-12-10T22:30:50Z |
| format | Article |
| id | doaj.art-009214cbb77948d2a113771ec02f761f |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-10T22:30:50Z |
| publishDate | 2014-09-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-009214cbb77948d2a113771ec02f761f2022-12-22T01:31:03Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422014-09-01869454828568Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertensionV V DolgikhS E Bol'shakovaL I KolesnikovaI M MikhalevichAIM. To estimate the spread and distribution of genotypes and alleles of thrombosis predisposition gene polymorphisms in adolescents with essential hypertension (EH). MATERIALS AND METHODS. One hundred and thirty-seven 14- to 17-year-old adolescents were examined. There were 3 examined groups: 1) 37 EH patients with prothrombotic changes (PTC); 2) 60 EH patients without PTC; 3) 40 healthy adolescents. Prothrombin time, activated partial thromboplastin time, and the levels of fibrinogen and soluble fibrin monomer complexes were determined. The adolescents were assigned to a PTC group if they had changes by one or several above indicators. Polymerase chain reaction assay was used to type coagulation factor II (FII) and factor V (FV), plasminogen activator inhibitor type 1 (PAI-1), 5,10-methylenetetrahydrofolate reductase (MTHFR), and methionine syntase reductase (MTRR) gene polymorphisms. Group differences were determined by qualitative signs, by using the χ2 test and Yates' correction for continuity and Fisher's exact test if one of the groups had at least 5 individuals. All differences were considered statistically significant at phttps://ter-arkhiv.ru/0040-3660/article/view/31552hypertensionpolymorphismprothrombotic changesadolescents |
| spellingShingle | V V Dolgikh S E Bol'shakova L I Kolesnikova I M Mikhalevich Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension Терапевтический архив hypertension polymorphism prothrombotic changes adolescents |
| title | Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension |
| title_full | Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension |
| title_fullStr | Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension |
| title_full_unstemmed | Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension |
| title_short | Molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension |
| title_sort | molecular genetic markers of predisposition to thrombosis in adolescents with essential hypertension |
| topic | hypertension polymorphism prothrombotic changes adolescents |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31552 |
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