Crosstalk between Hepatitis B Virus and the 3D Genome Structure
Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expres...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/2/445 |
| _version_ | 1797475890020483072 |
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| author | João Diogo Dias Nazim Sarica Axel Cournac Romain Koszul Christine Neuveut |
| author_facet | João Diogo Dias Nazim Sarica Axel Cournac Romain Koszul Christine Neuveut |
| author_sort | João Diogo Dias |
| collection | DOAJ |
| description | Viruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization. |
| first_indexed | 2024-03-09T20:51:11Z |
| format | Article |
| id | doaj.art-0092731fc85f4d03903d724111f84b9b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T20:51:11Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-0092731fc85f4d03903d724111f84b9b2023-11-23T22:33:03ZengMDPI AGViruses1999-49152022-02-0114244510.3390/v14020445Crosstalk between Hepatitis B Virus and the 3D Genome StructureJoão Diogo Dias0Nazim Sarica1Axel Cournac2Romain Koszul3Christine Neuveut4Laboratoire de Virologie Moléculaire, Institut de Génétique Humaine, CNRS, Université de Montpellier, 34000 Montpellier, FranceLaboratoire de Virologie Moléculaire, Institut de Génétique Humaine, CNRS, Université de Montpellier, 34000 Montpellier, FranceUnité Régulation Spatiale des Génomes, CNRS, UMR 3525, Institut Pasteur, Université de Paris, 75015 Paris, FranceUnité Régulation Spatiale des Génomes, CNRS, UMR 3525, Institut Pasteur, Université de Paris, 75015 Paris, FranceLaboratoire de Virologie Moléculaire, Institut de Génétique Humaine, CNRS, Université de Montpellier, 34000 Montpellier, FranceViruses that transcribe their DNA within the nucleus have to adapt to the existing cellular mechanisms that govern transcriptional regulation. Recent technological breakthroughs have highlighted the highly hierarchical organization of the cellular genome and its role in the regulation of gene expression. This review provides an updated overview on the current knowledge on how the hepatitis B virus interacts with the cellular 3D genome and its consequences on viral and cellular gene expression. We also briefly discuss the strategies developed by other DNA viruses to co-opt and sometimes subvert cellular genome spatial organization.https://www.mdpi.com/1999-4915/14/2/445HBVHBV cccDNAspatial nuclear organizationgene regulationDNA viruses |
| spellingShingle | João Diogo Dias Nazim Sarica Axel Cournac Romain Koszul Christine Neuveut Crosstalk between Hepatitis B Virus and the 3D Genome Structure Viruses HBV HBV cccDNA spatial nuclear organization gene regulation DNA viruses |
| title | Crosstalk between Hepatitis B Virus and the 3D Genome Structure |
| title_full | Crosstalk between Hepatitis B Virus and the 3D Genome Structure |
| title_fullStr | Crosstalk between Hepatitis B Virus and the 3D Genome Structure |
| title_full_unstemmed | Crosstalk between Hepatitis B Virus and the 3D Genome Structure |
| title_short | Crosstalk between Hepatitis B Virus and the 3D Genome Structure |
| title_sort | crosstalk between hepatitis b virus and the 3d genome structure |
| topic | HBV HBV cccDNA spatial nuclear organization gene regulation DNA viruses |
| url | https://www.mdpi.com/1999-4915/14/2/445 |
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