The essential role of t cells in multiple sclerosis: A reappraisal
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which destruction of myelin and nerve axons has been shown to be mediated by immune mechanisms. Although the focus of research has been traditionally on T cells as key mediators of the immunopathology, more...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=2;spage=34;epage=40;aulast=Constantinescu |
| _version_ | 1828354928745119744 |
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| author | Cris S Constantinescu Bruno Gran |
| author_facet | Cris S Constantinescu Bruno Gran |
| author_sort | Cris S Constantinescu |
| collection | DOAJ |
| description | Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which destruction of myelin and nerve axons has been shown to be mediated by immune mechanisms. Although the focus of research has been traditionally on T cells as key mediators of the immunopathology, more recent efforts at understanding this complex disorder have been directed increasingly at other cellular and humoral elements of the immune response. This review is a reappraisal of the crucial role of T cells, in particular the CD4+ helper T-cell subset, in multiple sclerosis. Recent evidence is discussed underlining the predominant contribution of T-cell-associated genes to the genome-wide association study results of multiple sclerosis susceptibility, the loss of T-cell quiescence in the conversion from clinically isolated syndrome to clinically definite multiple sclerosis, and the fact that T cells represent the main target of effective immunomodulatory and immunosuppressive treatments in multiple sclerosis. |
| first_indexed | 2024-04-14T02:32:51Z |
| format | Article |
| id | doaj.art-0093575a29f04ab18d05a61e6559ec21 |
| institution | Directory Open Access Journal |
| issn | 2319-4170 2320-2890 |
| language | English |
| last_indexed | 2024-04-14T02:32:51Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-0093575a29f04ab18d05a61e6559ec212022-12-22T02:17:35ZengElsevierBiomedical Journal2319-41702320-28902014-04-01372344010.4103/2319-4170.128746The essential role of t cells in multiple sclerosis: A reappraisalCris S Constantinescu0Bruno Gran1Clinical Neurology Research Group, Division of Clinical Neuroscience, University of Nottingham School of Medicine, Queen's Medical Centre, Nottingham, United KingdomClinical Neurology Research Group, Division of Clinical Neuroscience, University of Nottingham School of Medicine, Queen's Medical Centre, Nottingham, United KingdomMultiple sclerosis is an inflammatory demyelinating disease of the central nervous system in which destruction of myelin and nerve axons has been shown to be mediated by immune mechanisms. Although the focus of research has been traditionally on T cells as key mediators of the immunopathology, more recent efforts at understanding this complex disorder have been directed increasingly at other cellular and humoral elements of the immune response. This review is a reappraisal of the crucial role of T cells, in particular the CD4+ helper T-cell subset, in multiple sclerosis. Recent evidence is discussed underlining the predominant contribution of T-cell-associated genes to the genome-wide association study results of multiple sclerosis susceptibility, the loss of T-cell quiescence in the conversion from clinically isolated syndrome to clinically definite multiple sclerosis, and the fact that T cells represent the main target of effective immunomodulatory and immunosuppressive treatments in multiple sclerosis.http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=2;spage=34;epage=40;aulast=Constantinescuexperimental autoimmune encephalomyelitishookwormmultiple sclerosisTh17Th1 Tregtreatment |
| spellingShingle | Cris S Constantinescu Bruno Gran The essential role of t cells in multiple sclerosis: A reappraisal Biomedical Journal experimental autoimmune encephalomyelitis hookworm multiple sclerosis Th17 Th1 Treg treatment |
| title | The essential role of t cells in multiple sclerosis: A reappraisal |
| title_full | The essential role of t cells in multiple sclerosis: A reappraisal |
| title_fullStr | The essential role of t cells in multiple sclerosis: A reappraisal |
| title_full_unstemmed | The essential role of t cells in multiple sclerosis: A reappraisal |
| title_short | The essential role of t cells in multiple sclerosis: A reappraisal |
| title_sort | essential role of t cells in multiple sclerosis a reappraisal |
| topic | experimental autoimmune encephalomyelitis hookworm multiple sclerosis Th17 Th1 Treg treatment |
| url | http://www.biomedj.org/article.asp?issn=2319-4170;year=2014;volume=37;issue=2;spage=34;epage=40;aulast=Constantinescu |
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