Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions
Introduction: Leprosy reactions, classified as type 1 and type 2 reactions, are acute clinical conditions of exacerbation of localized or systemic inflammatory response inpatients with leprosy. No laboratory biomarker is available to predict the emergence of these reactions. Neutrophil-to-lymphocyte...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020302140 |
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| author | Luciano Teixeira Gomes Yvelise Terezinha Morato-Conceição Ana Vitória Mota Gambati Carolina Mira Maciel-Pereira Cor Jesus Fernandes Fontes |
| author_facet | Luciano Teixeira Gomes Yvelise Terezinha Morato-Conceição Ana Vitória Mota Gambati Carolina Mira Maciel-Pereira Cor Jesus Fernandes Fontes |
| author_sort | Luciano Teixeira Gomes |
| collection | DOAJ |
| description | Introduction: Leprosy reactions, classified as type 1 and type 2 reactions, are acute clinical conditions of exacerbation of localized or systemic inflammatory response inpatients with leprosy. No laboratory biomarker is available to predict the emergence of these reactions. Neutrophil-to-lymphocyte ratio (NLR) is an accurate biomarker for diagnosis and prognosis of various inflammatory and neoplastic diseases. Objective: This study aimed to investigate the accuracy of the NLR in the diagnosis of leprosy reactions. Materials and methods: NLR was calculated for all patients and a receiver operating characteristic curve (ROC) were generated to identify the NLR cut-off point. Results: A total of 123 patients with leprosy were included, 98 with leprosy reactions of which 56 (45.5%) had type 1 and 42 (34.1%) with type 2. Mean NLR was higher among patients with reactions than among those without. It was also statistically higher among patients with type 2 reactions than in those with type 1 reactions. Receiver operating characteristic curves were generated to identify the NLR cut-off point. The area under the ROC curve was 0.794 for diagnosis of any leprosy reaction and 0.796 for the diagnosis of type 2 reaction. The NLR cut-off points for diagnosis of any leprosy reaction and for type 2 reaction were 2.75 (sensitivity 61.0%, specificity 92.0%, accuracy 77.0%) and 2.95 (sensitivity 81.0%, specificity 74.0%, accuracy 78.0%), respectively. Conclusion: These results suggest that NLR could be a potential biomarker for diagnosis of leprosy reaction and useful for discriminating patients with type 2 reactions from those with type 1 leprosy reactions. |
| first_indexed | 2024-12-12T10:03:50Z |
| format | Article |
| id | doaj.art-00942ee46b804f6b92b2a2bd45be7646 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T10:03:50Z |
| publishDate | 2020-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-00942ee46b804f6b92b2a2bd45be76462022-12-22T00:27:56ZengElsevierHeliyon2405-84402020-02-0162e03369Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactionsLuciano Teixeira Gomes0Yvelise Terezinha Morato-Conceição1Ana Vitória Mota Gambati2Carolina Mira Maciel-Pereira3Cor Jesus Fernandes Fontes4Júlio Müller University Hospital, Department of Infectious Diseases, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil; Corresponding author.Júlio Müller University Hospital, Department of Infectious Diseases, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Mato Grosso, BrazilFaculty of Biomedical Sciences of Cacoal, Cacoal, Rondonia, BrazilFaculty of Biomedical Sciences of Cacoal, Cacoal, Rondonia, BrazilJúlio Müller University Hospital, Department of Infectious Diseases, Faculty of Medicine, Federal University of Mato Grosso, Cuiabá, Mato Grosso, Brazil; Faculty of Biomedical Sciences of Cacoal, Cacoal, Rondonia, BrazilIntroduction: Leprosy reactions, classified as type 1 and type 2 reactions, are acute clinical conditions of exacerbation of localized or systemic inflammatory response inpatients with leprosy. No laboratory biomarker is available to predict the emergence of these reactions. Neutrophil-to-lymphocyte ratio (NLR) is an accurate biomarker for diagnosis and prognosis of various inflammatory and neoplastic diseases. Objective: This study aimed to investigate the accuracy of the NLR in the diagnosis of leprosy reactions. Materials and methods: NLR was calculated for all patients and a receiver operating characteristic curve (ROC) were generated to identify the NLR cut-off point. Results: A total of 123 patients with leprosy were included, 98 with leprosy reactions of which 56 (45.5%) had type 1 and 42 (34.1%) with type 2. Mean NLR was higher among patients with reactions than among those without. It was also statistically higher among patients with type 2 reactions than in those with type 1 reactions. Receiver operating characteristic curves were generated to identify the NLR cut-off point. The area under the ROC curve was 0.794 for diagnosis of any leprosy reaction and 0.796 for the diagnosis of type 2 reaction. The NLR cut-off points for diagnosis of any leprosy reaction and for type 2 reaction were 2.75 (sensitivity 61.0%, specificity 92.0%, accuracy 77.0%) and 2.95 (sensitivity 81.0%, specificity 74.0%, accuracy 78.0%), respectively. Conclusion: These results suggest that NLR could be a potential biomarker for diagnosis of leprosy reaction and useful for discriminating patients with type 2 reactions from those with type 1 leprosy reactions.http://www.sciencedirect.com/science/article/pii/S2405844020302140Health sciencesInfectious diseaseMedical microbiologyClinical researchDiagnosticsBiomarkers |
| spellingShingle | Luciano Teixeira Gomes Yvelise Terezinha Morato-Conceição Ana Vitória Mota Gambati Carolina Mira Maciel-Pereira Cor Jesus Fernandes Fontes Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions Heliyon Health sciences Infectious disease Medical microbiology Clinical research Diagnostics Biomarkers |
| title | Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions |
| title_full | Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions |
| title_fullStr | Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions |
| title_full_unstemmed | Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions |
| title_short | Diagnostic value of neutrophil-to-lymphocyte ratio in patients with leprosy reactions |
| title_sort | diagnostic value of neutrophil to lymphocyte ratio in patients with leprosy reactions |
| topic | Health sciences Infectious disease Medical microbiology Clinical research Diagnostics Biomarkers |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020302140 |
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