The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness
Aim: To determine the value of gene polymorphisms of interleukin-28B (IL28B), RNase L, HLA DRB1*1101 and HLADQB1*03 alleles as predictors of antiviral treatment efficacy in patients with chronic hepatitis C (CHC).Material and methods. A total of 156 in-patients with chronic hepatitis C (65.4% men, 6...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2014-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/237 |
| _version_ | 1797759090456264704 |
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| author | V. M. Mitsura |
| author_facet | V. M. Mitsura |
| author_sort | V. M. Mitsura |
| collection | DOAJ |
| description | Aim: To determine the value of gene polymorphisms of interleukin-28B (IL28B), RNase L, HLA DRB1*1101 and HLADQB1*03 alleles as predictors of antiviral treatment efficacy in patients with chronic hepatitis C (CHC).Material and methods. A total of 156 in-patients with chronic hepatitis C (65.4% men, 62.4% had genotype 1 hepatitis C virus – HCV) were studied. The results of treatment with interferon (IFN) and ribavirin (RBV) were analyzed in 74 patients. Polymerase chain reaction identified single nucleotide polymorphisms (SNP) of the gene IL28B 39743165T>G (rs8099917), SNP 39738787C> T (rs12979860), RNase L gene (1385G>A), HLA DRB1*1101 and HLA-DQB1*03 alleles.Results. In patients with HCV genotype 1 mutant alleles were more common in SNP 39743165T>G (p=0.001) and 39738787C>T (p=0.0002) than in patients with other genotypes. Response to therapy IFN/RBV was higher in those with “favorable” TT variant (SNP 39743165T>G) and CC (SNP 39738787C>T), in those with their combination virologic response ffect were found according to genes IL28B and RNase L SNP variants, DRB1*1101 and HLA-DQB1*03 alleles.Conclusion. Testing for SNP 39738787C>T of IL28B gene is recommended before starting therapy IFN / RBV for all patients with genotype 1 HCV as a predictor of treatment response. Testing SNP 1385G>A gene RNase L and DRB1*1101, HLA-DQB1*03 alleles has no apparent prognostic value for patients with CHC antiviral therapy. |
| first_indexed | 2024-03-12T18:39:27Z |
| format | Article |
| id | doaj.art-0097571484884821a3e0e259856aaf71 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2024-03-12T18:39:27Z |
| publishDate | 2014-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-0097571484884821a3e0e259856aaf712023-08-02T07:52:24ZrusJournal InfectologyЖурнал инфектологии2072-67322014-09-0162485410.22625/2072-6732-2014-6-2-48-54251The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectivenessV. M. Mitsura0Гомельский государственный медицинский университет, Гомель, БеларусьAim: To determine the value of gene polymorphisms of interleukin-28B (IL28B), RNase L, HLA DRB1*1101 and HLADQB1*03 alleles as predictors of antiviral treatment efficacy in patients with chronic hepatitis C (CHC).Material and methods. A total of 156 in-patients with chronic hepatitis C (65.4% men, 62.4% had genotype 1 hepatitis C virus – HCV) were studied. The results of treatment with interferon (IFN) and ribavirin (RBV) were analyzed in 74 patients. Polymerase chain reaction identified single nucleotide polymorphisms (SNP) of the gene IL28B 39743165T>G (rs8099917), SNP 39738787C> T (rs12979860), RNase L gene (1385G>A), HLA DRB1*1101 and HLA-DQB1*03 alleles.Results. In patients with HCV genotype 1 mutant alleles were more common in SNP 39743165T>G (p=0.001) and 39738787C>T (p=0.0002) than in patients with other genotypes. Response to therapy IFN/RBV was higher in those with “favorable” TT variant (SNP 39743165T>G) and CC (SNP 39738787C>T), in those with their combination virologic response ffect were found according to genes IL28B and RNase L SNP variants, DRB1*1101 and HLA-DQB1*03 alleles.Conclusion. Testing for SNP 39738787C>T of IL28B gene is recommended before starting therapy IFN / RBV for all patients with genotype 1 HCV as a predictor of treatment response. Testing SNP 1385G>A gene RNase L and DRB1*1101, HLA-DQB1*03 alleles has no apparent prognostic value for patients with CHC antiviral therapy.https://journal.niidi.ru/jofin/article/view/237полиморфизм гена ил-28bрнка- за lhla-drb1*11hla-dqb1*03хронический гепатит синтерферонотерапия |
| spellingShingle | V. M. Mitsura The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness Журнал инфектологии полиморфизм гена ил-28b рнка- за l hla-drb1*11 hla-dqb1*03 хронический гепатит с интерферонотерапия |
| title | The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness |
| title_full | The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness |
| title_fullStr | The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness |
| title_full_unstemmed | The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness |
| title_short | The value of some genetic factors for prediction of chronic hepatitis C antiviral treatment effectiveness |
| title_sort | value of some genetic factors for prediction of chronic hepatitis c antiviral treatment effectiveness |
| topic | полиморфизм гена ил-28b рнка- за l hla-drb1*11 hla-dqb1*03 хронический гепатит с интерферонотерапия |
| url | https://journal.niidi.ru/jofin/article/view/237 |
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