The Detrimental Action of Adenosine on Glutamate-Induced Cytotoxicity in PC12 Cells Can Be Shifted towards a Neuroprotective Role through A<sub>1</sub>AR Positive Allosteric Modulation

The Detrimental Action of Adenosine on Glutamate-Induced Cytotoxicity in PC12 Cells Can Be Shifted towards a Neuroprotective Role through A<sub>1</sub>AR Positive Allosteric Modulation

Glutamate cytotoxicity is implicated in neuronal death in different neurological disorders including stroke, traumatic brain injury, and neurodegenerative diseases. Adenosine is a nucleoside that plays an important role in modulating neuronal activity and its receptors have been identified as promis...

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Bibliographic Details
Main Authors: Fabrizio Vincenzi, Silvia Pasquini, Stefania Gessi, Stefania Merighi, Romeo Romagnoli, Pier Andrea Borea, Katia Varani
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
adenosine
glutamate cytotoxicity
positive allosteric modulation
neuroprotection
apoptosis
Online Access:https://www.mdpi.com/2073-4409/9/5/1242

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