Promising derivatives of rutaecarpine with diverse pharmacological activities
Rutaecarpine (RUT) is a natural pentacyclic indolopyridoquinazolinone alkaloid first isolated from one of the most famous traditional Chinese herbs, Evodia rutaecarpa, which is used for treating a variety of ailments, including headaches, gastrointestinal disorders, postpartum hemorrhage, amenorrhea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2023.1199799/full |
| _version_ | 1797643235876667392 |
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| author | Deping Li Ziqian Huang Xiaojun Xu Yan Li |
| author_facet | Deping Li Ziqian Huang Xiaojun Xu Yan Li |
| author_sort | Deping Li |
| collection | DOAJ |
| description | Rutaecarpine (RUT) is a natural pentacyclic indolopyridoquinazolinone alkaloid first isolated from one of the most famous traditional Chinese herbs, Evodia rutaecarpa, which is used for treating a variety of ailments, including headaches, gastrointestinal disorders, postpartum hemorrhage, amenorrhea, difficult menstruation, and other diseases. Accumulating pharmacological studies showed that RUT possesses a wide range of pharmacological effects through different mechanisms. However, its poor physicochemical properties and moderate biological activities have hampered its clinical application. In this regard, the modification of RUT aimed at seeking its derivatives with better physicochemical properties and more potency has been extensively studied. These derivatives exhibit diverse pharmacological activities, including anti-inflammatory, anti-atherogenic, anti-Alzheimer’s disease, antitumor, and antifungal activities via a variety of mechanisms, such as inhibiting cyclooxygenase-2 (COX-2), acetylcholine (AChE), phosphodiesterase 4B (PDE4B), phosphodiesterase 5 (PDE5), or topoisomerases (Topos). From this perspective, this paper provides a comprehensive description of RUT derivatives by focusing on their diverse biological activities. This review aims to give an insight into the biological activities of RUT derivatives and encourage further exploration of RUT. |
| first_indexed | 2024-03-11T14:11:48Z |
| format | Article |
| id | doaj.art-0099d731cc8948ca8b0500e2d79d32f9 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-03-11T14:11:48Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-0099d731cc8948ca8b0500e2d79d32f92023-11-01T17:25:26ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462023-11-011110.3389/fchem.2023.11997991199799Promising derivatives of rutaecarpine with diverse pharmacological activitiesDeping Li0Ziqian Huang1Xiaojun Xu2Yan Li3Department of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Party and Government Office, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaDepartment of Pharmacy, First Affiliated Hospital of Gannan Medical University, Ganzhou, ChinaRutaecarpine (RUT) is a natural pentacyclic indolopyridoquinazolinone alkaloid first isolated from one of the most famous traditional Chinese herbs, Evodia rutaecarpa, which is used for treating a variety of ailments, including headaches, gastrointestinal disorders, postpartum hemorrhage, amenorrhea, difficult menstruation, and other diseases. Accumulating pharmacological studies showed that RUT possesses a wide range of pharmacological effects through different mechanisms. However, its poor physicochemical properties and moderate biological activities have hampered its clinical application. In this regard, the modification of RUT aimed at seeking its derivatives with better physicochemical properties and more potency has been extensively studied. These derivatives exhibit diverse pharmacological activities, including anti-inflammatory, anti-atherogenic, anti-Alzheimer’s disease, antitumor, and antifungal activities via a variety of mechanisms, such as inhibiting cyclooxygenase-2 (COX-2), acetylcholine (AChE), phosphodiesterase 4B (PDE4B), phosphodiesterase 5 (PDE5), or topoisomerases (Topos). From this perspective, this paper provides a comprehensive description of RUT derivatives by focusing on their diverse biological activities. This review aims to give an insight into the biological activities of RUT derivatives and encourage further exploration of RUT.https://www.frontiersin.org/articles/10.3389/fchem.2023.1199799/fullrutaecarpinealkaloidnatural productsbioactivityevodiamineβ-carboline |
| spellingShingle | Deping Li Ziqian Huang Xiaojun Xu Yan Li Promising derivatives of rutaecarpine with diverse pharmacological activities Frontiers in Chemistry rutaecarpine alkaloid natural products bioactivity evodiamine β-carboline |
| title | Promising derivatives of rutaecarpine with diverse pharmacological activities |
| title_full | Promising derivatives of rutaecarpine with diverse pharmacological activities |
| title_fullStr | Promising derivatives of rutaecarpine with diverse pharmacological activities |
| title_full_unstemmed | Promising derivatives of rutaecarpine with diverse pharmacological activities |
| title_short | Promising derivatives of rutaecarpine with diverse pharmacological activities |
| title_sort | promising derivatives of rutaecarpine with diverse pharmacological activities |
| topic | rutaecarpine alkaloid natural products bioactivity evodiamine β-carboline |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2023.1199799/full |
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