Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna
OBJECTIVES: This retrospective study performed a comprehensive analysis of the usage of intra-arterial chemotherapy (iaCh) for locally recurrent UICC stage IV oral squamous cell carcinoma (OSCC) over two decades at the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Vi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier España
2018-10-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100272&lng=en&tlng=en |
| _version_ | 1811317171863683072 |
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| author | Christina Eder-Czembirek Sascha Rechinger Gabriela Kornek Edgar Selzer Rudolf Seemann |
| author_facet | Christina Eder-Czembirek Sascha Rechinger Gabriela Kornek Edgar Selzer Rudolf Seemann |
| author_sort | Christina Eder-Czembirek |
| collection | DOAJ |
| description | OBJECTIVES: This retrospective study performed a comprehensive analysis of the usage of intra-arterial chemotherapy (iaCh) for locally recurrent UICC stage IV oral squamous cell carcinoma (OSCC) over two decades at the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Vienna to assess the utility of its future use. METHODS: Between 1994 and 2014, iaCh was indicated in 48 OSCC cases. In these, the two most frequent iaCh schemes, cisplatin/5-fluorouracil (Cis/5-FU) and methotrexate/bleomycin (MTX/Bleo), were chosen for further analysis. The effect on survival of two distinct intra-arterial protocols and their covariates were analyzed with the Kaplan-Meier method as well as univariate and multivariate Cox proportional hazard regression models. RESULTS: The mean follow-up period was 29.91 months. The two intra-arterial chemotherapy groups did not differ significantly in sample size, demographic data or therapeutic covariates. The Cis/5-FU iaCh regimen was associated with significantly better overall survival (median OS 2.6 years vs. 1.3 years; p=0.002) and had a beneficial effect on survival (HR=3.62, p=0.015). Side effects occurred at a frequency similar to that described in the literature for intravenous chemotherapy (ivCh). CONCLUSIONS: These results suggest a preference for administering Cis/5-FU for iaCh. Nevertheless, due to economic considerations in healthcare expenditures, there is no future for iaCh in the treatment of head and neck carcinomas because ivCh is known to be equivalent. |
| first_indexed | 2024-04-13T12:02:15Z |
| format | Article |
| id | doaj.art-009c63f9f96e4d7480f8f08cbab76d0f |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-13T12:02:15Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-009c63f9f96e4d7480f8f08cbab76d0f2022-12-22T02:47:44ZengElsevier EspañaClinics1980-53222018-10-0173010.6061/clinics/2018/e433S1807-59322018000100272Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital ViennaChristina Eder-CzembirekSascha RechingerGabriela KornekEdgar SelzerRudolf SeemannOBJECTIVES: This retrospective study performed a comprehensive analysis of the usage of intra-arterial chemotherapy (iaCh) for locally recurrent UICC stage IV oral squamous cell carcinoma (OSCC) over two decades at the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Vienna to assess the utility of its future use. METHODS: Between 1994 and 2014, iaCh was indicated in 48 OSCC cases. In these, the two most frequent iaCh schemes, cisplatin/5-fluorouracil (Cis/5-FU) and methotrexate/bleomycin (MTX/Bleo), were chosen for further analysis. The effect on survival of two distinct intra-arterial protocols and their covariates were analyzed with the Kaplan-Meier method as well as univariate and multivariate Cox proportional hazard regression models. RESULTS: The mean follow-up period was 29.91 months. The two intra-arterial chemotherapy groups did not differ significantly in sample size, demographic data or therapeutic covariates. The Cis/5-FU iaCh regimen was associated with significantly better overall survival (median OS 2.6 years vs. 1.3 years; p=0.002) and had a beneficial effect on survival (HR=3.62, p=0.015). Side effects occurred at a frequency similar to that described in the literature for intravenous chemotherapy (ivCh). CONCLUSIONS: These results suggest a preference for administering Cis/5-FU for iaCh. Nevertheless, due to economic considerations in healthcare expenditures, there is no future for iaCh in the treatment of head and neck carcinomas because ivCh is known to be equivalent.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100272&lng=en&tlng=enIntra-Arterial ChemotherapyOral Squamous Cell CarcinomaLocally RecurrentCisplatinMethotrexateHead and Neck |
| spellingShingle | Christina Eder-Czembirek Sascha Rechinger Gabriela Kornek Edgar Selzer Rudolf Seemann Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna Clinics Intra-Arterial Chemotherapy Oral Squamous Cell Carcinoma Locally Recurrent Cisplatin Methotrexate Head and Neck |
| title | Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna |
| title_full | Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna |
| title_fullStr | Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna |
| title_full_unstemmed | Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna |
| title_short | Experience in Intra-arterial Chemotherapy using Two Protocols for the Treatment of OSCC over Two Decades at the University Hospital Vienna |
| title_sort | experience in intra arterial chemotherapy using two protocols for the treatment of oscc over two decades at the university hospital vienna |
| topic | Intra-Arterial Chemotherapy Oral Squamous Cell Carcinoma Locally Recurrent Cisplatin Methotrexate Head and Neck |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100272&lng=en&tlng=en |
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