Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients
Background: The etiology of Systemic lupus erythematosus seems to be multifactorial including environmental as well as genetic factors. The genetic predisposition was supported by the occurrence of Systemic lupus erythematosus in more than one member of a family as well as in identical twins. Aim o...
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| Format: | Article |
| Language: | English |
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University of Baghdad/ Al-Kindy College of Medicine
2012-12-01
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| Series: | مجله كليه طب الكندي |
| Subjects: | |
| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/589 |
| _version_ | 1798036479208849408 |
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| author | Hyam Raouf Al-Hammamy Kais Hasan Abd Iqbal Ali Khalil Batool Mutar Mahdi |
| author_facet | Hyam Raouf Al-Hammamy Kais Hasan Abd Iqbal Ali Khalil Batool Mutar Mahdi |
| author_sort | Hyam Raouf Al-Hammamy |
| collection | DOAJ |
| description |
Background: The etiology of Systemic lupus erythematosus seems to be multifactorial including environmental as well as genetic factors. The genetic predisposition was supported by the occurrence of Systemic lupus erythematosus in more than one member of a family as well as in identical twins.
Aim of the study: To determine the human leukocyte antigen typing class I (A and B) in patients with Systemic Lupus Erythematousus disease.
Methods: Patients group consisted of 44 Iraqi Arab Muslims patients with Systemic lupus erythematosus disease who presented to Baghdad Medical City from January 2010 to January 2012 from Baghdad Province. The second control group consisted from 80 Iraqi Arab Muslims volunteers from hospital employees and their relatives. Human leukocyte antigen typing done for them using serological method by microlymphocytotoxicity test.
Results: A total of 44 patients with Systemic lupus erythematosus were studied. Patients' age ranged from 6 to 65 years with a mean of 29.61 ± 12.78. The other control group, their ages ranged from 16 to 55 years with a mean of 31.35 ± 10.02 . Females were more than males in both groups. Human leukocyte antigen typing of Systemic lupus erythematosus patients showed A2( 16, 36.36, 0.20), A3( 14, 31.82, 0.17), B4(10, 22.73, 0.12) , B12 (10, 22.73, 0.12) and B21(10, 22.73, 0.12) were the highest absolute numbers, phenotype frequencies and genotype frequencies respectively. There was a significant difference in between SLE patients and control group in the following alleles (A1, A28, A36, A43,B 6, B12, B14, B15, B16, B35, B42, B53).
Conclusions: Genetic factors do have a role in the development and expression of Systemic lupus erythematosus . human leukocyte antigen -A28 , A36, B12 and B21 had an association with Systemic lupus erythematosus Iraqi patients.
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| first_indexed | 2024-04-11T21:13:31Z |
| format | Article |
| id | doaj.art-009ca0bb998b4bba875f6ed9c55870eb |
| institution | Directory Open Access Journal |
| issn | 1810-9543 2521-4365 |
| language | English |
| last_indexed | 2024-04-11T21:13:31Z |
| publishDate | 2012-12-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj.art-009ca0bb998b4bba875f6ed9c55870eb2022-12-22T04:02:53ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652012-12-0182Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi PatientsHyam Raouf Al-HammamyKais Hasan AbdIqbal Ali KhalilBatool Mutar Mahdi0Department Of Microbiology Al-Kindi College Of Medicine Baghdad University Background: The etiology of Systemic lupus erythematosus seems to be multifactorial including environmental as well as genetic factors. The genetic predisposition was supported by the occurrence of Systemic lupus erythematosus in more than one member of a family as well as in identical twins. Aim of the study: To determine the human leukocyte antigen typing class I (A and B) in patients with Systemic Lupus Erythematousus disease. Methods: Patients group consisted of 44 Iraqi Arab Muslims patients with Systemic lupus erythematosus disease who presented to Baghdad Medical City from January 2010 to January 2012 from Baghdad Province. The second control group consisted from 80 Iraqi Arab Muslims volunteers from hospital employees and their relatives. Human leukocyte antigen typing done for them using serological method by microlymphocytotoxicity test. Results: A total of 44 patients with Systemic lupus erythematosus were studied. Patients' age ranged from 6 to 65 years with a mean of 29.61 ± 12.78. The other control group, their ages ranged from 16 to 55 years with a mean of 31.35 ± 10.02 . Females were more than males in both groups. Human leukocyte antigen typing of Systemic lupus erythematosus patients showed A2( 16, 36.36, 0.20), A3( 14, 31.82, 0.17), B4(10, 22.73, 0.12) , B12 (10, 22.73, 0.12) and B21(10, 22.73, 0.12) were the highest absolute numbers, phenotype frequencies and genotype frequencies respectively. There was a significant difference in between SLE patients and control group in the following alleles (A1, A28, A36, A43,B 6, B12, B14, B15, B16, B35, B42, B53). Conclusions: Genetic factors do have a role in the development and expression of Systemic lupus erythematosus . human leukocyte antigen -A28 , A36, B12 and B21 had an association with Systemic lupus erythematosus Iraqi patients. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/589Human Leukocyte Antigens,Systemic Lupus ErythematosusTissue typing |
| spellingShingle | Hyam Raouf Al-Hammamy Kais Hasan Abd Iqbal Ali Khalil Batool Mutar Mahdi Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients مجله كليه طب الكندي Human Leukocyte Antigens, Systemic Lupus Erythematosus Tissue typing |
| title | Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients |
| title_full | Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients |
| title_fullStr | Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients |
| title_full_unstemmed | Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients |
| title_short | Human Leukocyte Antigens Assosiation with Systemic Lupus Arythematosus In Iraqi Patients |
| title_sort | human leukocyte antigens assosiation with systemic lupus arythematosus in iraqi patients |
| topic | Human Leukocyte Antigens, Systemic Lupus Erythematosus Tissue typing |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/589 |
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