A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli
Major histocompatibility class I (MHCI) molecules are well known for their immunological role in mediating tissue graft rejection. Recently, these molecules were discovered to be expressed in distinct neuronal subclasses, dispelling the long-held tenet that the uninjured brain is immune-privileged....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2013-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130044 |
| _version_ | 1819230926795702272 |
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| author | Ernesto Salcedo Nicole M. Cruz Xuan Ly Beth A. Welander Kyle Hanson Eugene Kronberg Diego Restrepo |
| author_facet | Ernesto Salcedo Nicole M. Cruz Xuan Ly Beth A. Welander Kyle Hanson Eugene Kronberg Diego Restrepo |
| author_sort | Ernesto Salcedo |
| collection | DOAJ |
| description | Major histocompatibility class I (MHCI) molecules are well known for their immunological role in mediating tissue graft rejection. Recently, these molecules were discovered to be expressed in distinct neuronal subclasses, dispelling the long-held tenet that the uninjured brain is immune-privileged. Here, we show that MHCI molecules are expressed in the main olfactory bulb (MOB) of adult animals. Furthermore, we find that mice with diminished levels of MHCI expression have enlarged MOBs containing an increased number of small, morphologically abnormal and ectopically located P2 glomeruli. These findings suggest that MHCI molecules may play an important role in the proper formation of glomeruli in the bulb. |
| first_indexed | 2024-12-23T11:36:50Z |
| format | Article |
| id | doaj.art-009cd2aa80f74b76b582ed887c661323 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-23T11:36:50Z |
| publishDate | 2013-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-009cd2aa80f74b76b582ed887c6613232022-12-21T17:48:38ZengThe Royal SocietyOpen Biology2046-24412013-01-013510.1098/rsob.130044130044A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruliErnesto SalcedoNicole M. CruzXuan LyBeth A. WelanderKyle HansonEugene KronbergDiego RestrepoMajor histocompatibility class I (MHCI) molecules are well known for their immunological role in mediating tissue graft rejection. Recently, these molecules were discovered to be expressed in distinct neuronal subclasses, dispelling the long-held tenet that the uninjured brain is immune-privileged. Here, we show that MHCI molecules are expressed in the main olfactory bulb (MOB) of adult animals. Furthermore, we find that mice with diminished levels of MHCI expression have enlarged MOBs containing an increased number of small, morphologically abnormal and ectopically located P2 glomeruli. These findings suggest that MHCI molecules may play an important role in the proper formation of glomeruli in the bulb.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130044olfactionmain histocompatibility complex ip2 glomerulusmain olfactory bulbmajor histocompatibility class i molecules |
| spellingShingle | Ernesto Salcedo Nicole M. Cruz Xuan Ly Beth A. Welander Kyle Hanson Eugene Kronberg Diego Restrepo A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli Open Biology olfaction main histocompatibility complex i p2 glomerulus main olfactory bulb major histocompatibility class i molecules |
| title | A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli |
| title_full | A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli |
| title_fullStr | A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli |
| title_full_unstemmed | A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli |
| title_short | A TAP1 null mutation leads to an enlarged olfactory bulb and supernumerary, ectopic olfactory glomeruli |
| title_sort | tap1 null mutation leads to an enlarged olfactory bulb and supernumerary ectopic olfactory glomeruli |
| topic | olfaction main histocompatibility complex i p2 glomerulus main olfactory bulb major histocompatibility class i molecules |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130044 |
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