Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings
In a previous attempt to achieve ileo-colonic targeting of bovine intestinal alkaline phosphatase (BIAP), we applied a pH-dependent coating, the ColoPulse coating, directly on powder bed printed (PBP) tablets. However, the high surface roughness necessitated an additional sub-coating layer [Nguyen,...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/9/2193 |
| _version_ | 1797577992763867136 |
|---|---|
| author | Khanh T. T. Nguyen Daan Zillen Franca F. M. van Heijningen Kjeld J. C. van Bommel Renz J. van Ee Henderik W. Frijlink Wouter L. J. Hinrichs |
| author_facet | Khanh T. T. Nguyen Daan Zillen Franca F. M. van Heijningen Kjeld J. C. van Bommel Renz J. van Ee Henderik W. Frijlink Wouter L. J. Hinrichs |
| author_sort | Khanh T. T. Nguyen |
| collection | DOAJ |
| description | In a previous attempt to achieve ileo-colonic targeting of bovine intestinal alkaline phosphatase (BIAP), we applied a pH-dependent coating, the ColoPulse coating, directly on powder bed printed (PBP) tablets. However, the high surface roughness necessitated an additional sub-coating layer [Nguyen, K. T. T., <i>Pharmaceutics</i> 2022]. In this study, we aimed to find a production method for PBP tablets containing BIAP that allows the direct application of coating systems. Alterations of the printing parameters, binder content, and printing layer height, when combined, were demonstrated to create visually less rough PBP tablets. The addition of ethanol vapor treatment further improved the surface’s smoothness significantly. These changes enabled the direct application of the ColoPulse, or enteric coating, without a sub-coating. In vitro release testing showed the desired ileo-colonic release or upper-intestinal release for ColoPulse or enteric-coated tablets, respectively. Tablets containing BIAP, encapsulated within an inulin glass, maintained a high enzymatic activity (over 95%) even after 2 months of storage at 2–8 °C. Importantly, the coating process did not affect the activity of BIAP. In this study, we demonstrate, for the first time, the successful production of PBP tablets with surfaces that are directly coatable with the ColoPulse coating while preserving the stability of the encapsulated biopharmaceutical, BIAP. |
| first_indexed | 2024-03-10T22:15:58Z |
| format | Article |
| id | doaj.art-009d36f2b6de4693ac92821e8c2b36f8 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T22:15:58Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-009d36f2b6de4693ac92821e8c2b36f82023-11-19T12:26:17ZengMDPI AGPharmaceutics1999-49232023-08-01159219310.3390/pharmaceutics15092193Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different CoatingsKhanh T. T. Nguyen0Daan Zillen1Franca F. M. van Heijningen2Kjeld J. C. van Bommel3Renz J. van Ee4Henderik W. Frijlink5Wouter L. J. Hinrichs6Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9700 RB Groningen, The NetherlandsThe Netherlands Organization for Applied Scientific Research (TNO), 5656 AE Eindhoven, The NetherlandsThe Netherlands Organization for Applied Scientific Research (TNO), 5656 AE Eindhoven, The NetherlandsThe Netherlands Organization for Applied Scientific Research (TNO), 5656 AE Eindhoven, The NetherlandsDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9700 RB Groningen, The NetherlandsDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, 9700 RB Groningen, The NetherlandsIn a previous attempt to achieve ileo-colonic targeting of bovine intestinal alkaline phosphatase (BIAP), we applied a pH-dependent coating, the ColoPulse coating, directly on powder bed printed (PBP) tablets. However, the high surface roughness necessitated an additional sub-coating layer [Nguyen, K. T. T., <i>Pharmaceutics</i> 2022]. In this study, we aimed to find a production method for PBP tablets containing BIAP that allows the direct application of coating systems. Alterations of the printing parameters, binder content, and printing layer height, when combined, were demonstrated to create visually less rough PBP tablets. The addition of ethanol vapor treatment further improved the surface’s smoothness significantly. These changes enabled the direct application of the ColoPulse, or enteric coating, without a sub-coating. In vitro release testing showed the desired ileo-colonic release or upper-intestinal release for ColoPulse or enteric-coated tablets, respectively. Tablets containing BIAP, encapsulated within an inulin glass, maintained a high enzymatic activity (over 95%) even after 2 months of storage at 2–8 °C. Importantly, the coating process did not affect the activity of BIAP. In this study, we demonstrate, for the first time, the successful production of PBP tablets with surfaces that are directly coatable with the ColoPulse coating while preserving the stability of the encapsulated biopharmaceutical, BIAP.https://www.mdpi.com/1999-4923/15/9/21933D printingpowder bed printingpersonalized medicinebiologicsformulationsurface analysis |
| spellingShingle | Khanh T. T. Nguyen Daan Zillen Franca F. M. van Heijningen Kjeld J. C. van Bommel Renz J. van Ee Henderik W. Frijlink Wouter L. J. Hinrichs Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings Pharmaceutics 3D printing powder bed printing personalized medicine biologics formulation surface analysis |
| title | Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings |
| title_full | Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings |
| title_fullStr | Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings |
| title_full_unstemmed | Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings |
| title_short | Surface Engineering Methods for Powder Bed Printed Tablets to Optimize External Smoothness and Facilitate the Application of Different Coatings |
| title_sort | surface engineering methods for powder bed printed tablets to optimize external smoothness and facilitate the application of different coatings |
| topic | 3D printing powder bed printing personalized medicine biologics formulation surface analysis |
| url | https://www.mdpi.com/1999-4923/15/9/2193 |
| work_keys_str_mv | AT khanhttnguyen surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings AT daanzillen surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings AT francafmvanheijningen surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings AT kjeldjcvanbommel surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings AT renzjvanee surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings AT henderikwfrijlink surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings AT wouterljhinrichs surfaceengineeringmethodsforpowderbedprintedtabletstooptimizeexternalsmoothnessandfacilitatetheapplicationofdifferentcoatings |