Vascular calcification of chronic kidney disease: A brief review
Vascular calcification (VC) is highly prevalent among patients with chronic kidney disease (CKD). There is growing evidence that there is more underlying this condition than the histological presentation of atherosclerotic plaque and arteriosclerosis and that the risk of cardiovascular disease in th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=1;spage=34;epage=41;aulast=Hsu |
| _version_ | 1818578589635837952 |
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| author | Bang-Gee Hsu Jen-Pi Tsai |
| author_facet | Bang-Gee Hsu Jen-Pi Tsai |
| author_sort | Bang-Gee Hsu |
| collection | DOAJ |
| description | Vascular calcification (VC) is highly prevalent among patients with chronic kidney disease (CKD). There is growing evidence that there is more underlying this condition than the histological presentation of atherosclerotic plaque and arteriosclerosis and that the risk of cardiovascular disease in the context of CKD might be explained by the presence of VC. While VC has been observed in the absence of overt abnormal mineral metabolism, this association is coupled to abnormal homeostasis of minerals in patients with CKD, due to hyperphosphatemia and hypercalcemia. Furthermore, recent studies have shown that the differentiation of vascular smooth muscle cells into an osteogenic phenotype is highly regulated by pro-calcifying and anti-calcifying factors. There are several imaging modalities currently used in clinical practice to evaluate the extent and severity of VC; each has different advantages and limitations. Although there is no universally accepted method for the treatment of VC, there is growing evidence of the beneficial effects of medical therapy for the condition. This study discusses the mechanism underlying VC, imaging modalities used for evaluation of the condition, and possible treatments. |
| first_indexed | 2024-12-16T06:48:13Z |
| format | Article |
| id | doaj.art-009d765a57864b9ba58b330dc9de6ee8 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-16T06:48:13Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-009d765a57864b9ba58b330dc9de6ee82022-12-21T22:40:29ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562021-01-01331344110.4103/tcmj.tcmj_36_20Vascular calcification of chronic kidney disease: A brief reviewBang-Gee HsuJen-Pi TsaiVascular calcification (VC) is highly prevalent among patients with chronic kidney disease (CKD). There is growing evidence that there is more underlying this condition than the histological presentation of atherosclerotic plaque and arteriosclerosis and that the risk of cardiovascular disease in the context of CKD might be explained by the presence of VC. While VC has been observed in the absence of overt abnormal mineral metabolism, this association is coupled to abnormal homeostasis of minerals in patients with CKD, due to hyperphosphatemia and hypercalcemia. Furthermore, recent studies have shown that the differentiation of vascular smooth muscle cells into an osteogenic phenotype is highly regulated by pro-calcifying and anti-calcifying factors. There are several imaging modalities currently used in clinical practice to evaluate the extent and severity of VC; each has different advantages and limitations. Although there is no universally accepted method for the treatment of VC, there is growing evidence of the beneficial effects of medical therapy for the condition. This study discusses the mechanism underlying VC, imaging modalities used for evaluation of the condition, and possible treatments.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=1;spage=34;epage=41;aulast=Hsucardiovascular diseasechronic kidney diseaseimagetreatmentvascular calcification |
| spellingShingle | Bang-Gee Hsu Jen-Pi Tsai Vascular calcification of chronic kidney disease: A brief review Tzu-Chi Medical Journal cardiovascular disease chronic kidney disease image treatment vascular calcification |
| title | Vascular calcification of chronic kidney disease: A brief review |
| title_full | Vascular calcification of chronic kidney disease: A brief review |
| title_fullStr | Vascular calcification of chronic kidney disease: A brief review |
| title_full_unstemmed | Vascular calcification of chronic kidney disease: A brief review |
| title_short | Vascular calcification of chronic kidney disease: A brief review |
| title_sort | vascular calcification of chronic kidney disease a brief review |
| topic | cardiovascular disease chronic kidney disease image treatment vascular calcification |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=1;spage=34;epage=41;aulast=Hsu |
| work_keys_str_mv | AT banggeehsu vascularcalcificationofchronickidneydiseaseabriefreview AT jenpitsai vascularcalcificationofchronickidneydiseaseabriefreview |