Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia
Abstract Background Serum amyloid A (SAA) is a major acute phase protein in horses which could be a useful tool for assessing clinical response to treatment of bacterial pneumonia in adult horses. Objectives To monitor SAA concentration in response to treatment and identify associations among SAA co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.16818 |
| _version_ | 1797729006553923584 |
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| author | Kate L. Hepworth‐Warren Krista Estell Bobby Cowles Deborah Amodie Mark Crisman |
| author_facet | Kate L. Hepworth‐Warren Krista Estell Bobby Cowles Deborah Amodie Mark Crisman |
| author_sort | Kate L. Hepworth‐Warren |
| collection | DOAJ |
| description | Abstract Background Serum amyloid A (SAA) is a major acute phase protein in horses which could be a useful tool for assessing clinical response to treatment of bacterial pneumonia in adult horses. Objectives To monitor SAA concentration in response to treatment and identify associations among SAA concentration, WBC and neutrophil counts, and fibrinogen in bacterial pneumonia in adult horses. Animals Eighteen adult horses with bacterial pneumonia. Methods Prospective clinical study. Horses hospitalized with bacterial pneumonia were enrolled and SAA concentration and vital signs were assessed daily. SAA concentration was measured by a handheld meter. CBC and plasma fibrinogen were assessed on days 0, 1, and 2, then every 3 days until discharge. Data were not normally distributed and therefore were log transformed. Log‐transformed data were analyzed and comparisons were performed on LSMeans by the 2‐sided Student's t‐test at the 5% level of significance. Results Geometric mean SAA concentration on day 0 was 537 μg/mL (SE 383 μg/mL). Geometric mean SAA concentration decreased significantly over time (P = .0001), peaking at day 2 (geomean 1038 μg/mL, SE 261.7 μg/mL) and decreasing until discharge. Plasma concentration of fibrinogen (P = .06), neutrophil count (P = .48), and WBC count (P = .07) did not change significantly over time. Conclusions and Clinical Importance SAA concentration decreased significantly over the course of treatment and correlated with clinical improvement of pneumonia whereas fibrinogen, neutrophil, and WBC counts did not. |
| first_indexed | 2024-03-12T11:22:36Z |
| format | Article |
| id | doaj.art-00a0c04c07a7494d9bbc0e55b2c29297 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-12T11:22:36Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-00a0c04c07a7494d9bbc0e55b2c292972023-09-01T14:18:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-09-013751917192210.1111/jvim.16818Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumoniaKate L. Hepworth‐Warren0Krista Estell1Bobby Cowles2Deborah Amodie3Mark Crisman4Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University Raleigh North Carolina USAVirginia Tech's Marion duPont Scott Equine Medical Center Leesburg Virginia USAZoetis Parsippany New Jersey USAZoetis Parsippany New Jersey USAZoetis Parsippany New Jersey USAAbstract Background Serum amyloid A (SAA) is a major acute phase protein in horses which could be a useful tool for assessing clinical response to treatment of bacterial pneumonia in adult horses. Objectives To monitor SAA concentration in response to treatment and identify associations among SAA concentration, WBC and neutrophil counts, and fibrinogen in bacterial pneumonia in adult horses. Animals Eighteen adult horses with bacterial pneumonia. Methods Prospective clinical study. Horses hospitalized with bacterial pneumonia were enrolled and SAA concentration and vital signs were assessed daily. SAA concentration was measured by a handheld meter. CBC and plasma fibrinogen were assessed on days 0, 1, and 2, then every 3 days until discharge. Data were not normally distributed and therefore were log transformed. Log‐transformed data were analyzed and comparisons were performed on LSMeans by the 2‐sided Student's t‐test at the 5% level of significance. Results Geometric mean SAA concentration on day 0 was 537 μg/mL (SE 383 μg/mL). Geometric mean SAA concentration decreased significantly over time (P = .0001), peaking at day 2 (geomean 1038 μg/mL, SE 261.7 μg/mL) and decreasing until discharge. Plasma concentration of fibrinogen (P = .06), neutrophil count (P = .48), and WBC count (P = .07) did not change significantly over time. Conclusions and Clinical Importance SAA concentration decreased significantly over the course of treatment and correlated with clinical improvement of pneumonia whereas fibrinogen, neutrophil, and WBC counts did not.https://doi.org/10.1111/jvim.16818acute phaseantimicrobialsequinemicrobiologypleuropneumoniarespiratory |
| spellingShingle | Kate L. Hepworth‐Warren Krista Estell Bobby Cowles Deborah Amodie Mark Crisman Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia Journal of Veterinary Internal Medicine acute phase antimicrobials equine microbiology pleuropneumonia respiratory |
| title | Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia |
| title_full | Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia |
| title_fullStr | Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia |
| title_full_unstemmed | Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia |
| title_short | Utility of serum amyloid A in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia |
| title_sort | utility of serum amyloid a in monitoring clinical response to antimicrobial treatment in horses with bacterial pneumonia |
| topic | acute phase antimicrobials equine microbiology pleuropneumonia respiratory |
| url | https://doi.org/10.1111/jvim.16818 |
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