High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease

High BTLA Expression Likely Contributes to Contraction of the Regulatory T Cell Subset in Lupus Disease

B and T lymphocyte attenuator (BTLA) is a co-inhibitory receptor that is expressed by lymphoid cells and regulates the immune response. Consistent with an inhibitory role for BTLA, the disease is exacerbated in BTLA-deficient lupus mice. We recently demonstrated that the BTLA pathway is altered in C...

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Bibliographic Details
Main Authors: Lucie Aubergeon, Matthieu Sawaf, Renaud Felten, Jacques-Eric Gottenberg, Hélène Dumortier, Fanny Monneaux
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
BTLA
HVEM
regulatory T cells
inhibitory receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.767099/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.767099/full

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