Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan
<p>Abstract</p> <p>Background</p> <p><it>Phlebotomus papatasi </it>the vector of cutaneous leishmaniasis (CL) is the most widely spread sand fly in Sudan. No data has previously been collected on insecticide susceptibility and/or resistance of this vector, a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-03-01
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| Series: | Parasites & Vectors |
| Online Access: | http://www.parasitesandvectors.com/content/5/1/46 |
| _version_ | 1828495852030656512 |
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| author | Hassan Mo'awia Widaa Sally Osman Osman Numiary Mona Ibrahim Mihad Abushama Hind |
| author_facet | Hassan Mo'awia Widaa Sally Osman Osman Numiary Mona Ibrahim Mihad Abushama Hind |
| author_sort | Hassan Mo'awia |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Phlebotomus papatasi </it>the vector of cutaneous leishmaniasis (CL) is the most widely spread sand fly in Sudan. No data has previously been collected on insecticide susceptibility and/or resistance of this vector, and a first study to establish a baseline data is reported here.</p> <p>Methods</p> <p>Sand flies were collected from Surogia village, (Khartoum State), Rahad Game Reserve (eastern Sudan) and White Nile area (Central Sudan) using light traps. Sand flies were reared in the Tropical Medicine Research Institute laboratory. The insecticide susceptibility status of first progeny (F1) of <it>P. papatasi </it>of each population was tested using WHO insecticide kits. Also, <it>P. papatasi </it>specimens from Surogia village and Rahad Game Reserve were assayed for activities of enzyme systems involved in insecticide resistance (acetylcholinesterase (AChE), non-specific carboxylesterases (EST), glutathione-S-transferases (GSTs) and cytochrome p450 monooxygenases (Cyt p450).</p> <p>Results</p> <p>Populations of <it>P. papatasi </it>from White Nile and Rahad Game Reserve were sensitive to dichlorodiphenyltrichloroethane (DDT), permethrin, malathion, and propoxur. However, the <it>P. papatasi </it>population from Surogia village was sensitive to DDT and permethrin but highly resistant to malathion and propoxur. Furthermore, <it>P. papatasi </it>of Surogia village had significantly higher insecticide detoxification enzyme activity than of those of Rahad Game Reserve. The sand fly population in Surogia displayed high AChE activity and only three specimens had elevated levels for EST and GST.</p> <p>Conclusions</p> <p>The study provided evidence for malathion and propoxur resistance in the sand fly population of Surogia village, which probably resulted from anti-malarial control activities carried out in the area during the past 50 years.</p> |
| first_indexed | 2024-12-11T12:19:51Z |
| format | Article |
| id | doaj.art-00a30a5f0fdf4a68aea862a37a38597c |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-11T12:19:51Z |
| publishDate | 2012-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-00a30a5f0fdf4a68aea862a37a38597c2022-12-22T01:07:34ZengBMCParasites & Vectors1756-33052012-03-01514610.1186/1756-3305-5-46Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, SudanHassan Mo'awiaWidaa SallyOsman OsmanNumiary MonaIbrahim MihadAbushama Hind<p>Abstract</p> <p>Background</p> <p><it>Phlebotomus papatasi </it>the vector of cutaneous leishmaniasis (CL) is the most widely spread sand fly in Sudan. No data has previously been collected on insecticide susceptibility and/or resistance of this vector, and a first study to establish a baseline data is reported here.</p> <p>Methods</p> <p>Sand flies were collected from Surogia village, (Khartoum State), Rahad Game Reserve (eastern Sudan) and White Nile area (Central Sudan) using light traps. Sand flies were reared in the Tropical Medicine Research Institute laboratory. The insecticide susceptibility status of first progeny (F1) of <it>P. papatasi </it>of each population was tested using WHO insecticide kits. Also, <it>P. papatasi </it>specimens from Surogia village and Rahad Game Reserve were assayed for activities of enzyme systems involved in insecticide resistance (acetylcholinesterase (AChE), non-specific carboxylesterases (EST), glutathione-S-transferases (GSTs) and cytochrome p450 monooxygenases (Cyt p450).</p> <p>Results</p> <p>Populations of <it>P. papatasi </it>from White Nile and Rahad Game Reserve were sensitive to dichlorodiphenyltrichloroethane (DDT), permethrin, malathion, and propoxur. However, the <it>P. papatasi </it>population from Surogia village was sensitive to DDT and permethrin but highly resistant to malathion and propoxur. Furthermore, <it>P. papatasi </it>of Surogia village had significantly higher insecticide detoxification enzyme activity than of those of Rahad Game Reserve. The sand fly population in Surogia displayed high AChE activity and only three specimens had elevated levels for EST and GST.</p> <p>Conclusions</p> <p>The study provided evidence for malathion and propoxur resistance in the sand fly population of Surogia village, which probably resulted from anti-malarial control activities carried out in the area during the past 50 years.</p>http://www.parasitesandvectors.com/content/5/1/46 |
| spellingShingle | Hassan Mo'awia Widaa Sally Osman Osman Numiary Mona Ibrahim Mihad Abushama Hind Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan Parasites & Vectors |
| title | Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan |
| title_full | Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan |
| title_fullStr | Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan |
| title_full_unstemmed | Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan |
| title_short | Insecticide resistance in the sand fly, <it>Phlebotomus papatasi </it>from Khartoum State, Sudan |
| title_sort | insecticide resistance in the sand fly it phlebotomus papatasi it from khartoum state sudan |
| url | http://www.parasitesandvectors.com/content/5/1/46 |
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