Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis
Osteoarticular tuberculosis constitutes about 3% of all tuberculosis cases. Early and accurate diagnosis of tuberculosis is a challenging problem especially in the case of osteoarticular tuberculosis owing to the lower number of bacilli. However, an accurate and timely diagnosis of the disease resul...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X16000140 |
| _version_ | 1819043201272512512 |
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| author | Nazia Rizvi Ajai Singh Manish Yadav Syed Rizwan Hussain Salma Siddiqui Vineet Kumar Sabir Ali Avinash Agarwal |
| author_facet | Nazia Rizvi Ajai Singh Manish Yadav Syed Rizwan Hussain Salma Siddiqui Vineet Kumar Sabir Ali Avinash Agarwal |
| author_sort | Nazia Rizvi |
| collection | DOAJ |
| description | Osteoarticular tuberculosis constitutes about 3% of all tuberculosis cases. Early and accurate diagnosis of tuberculosis is a challenging problem especially in the case of osteoarticular tuberculosis owing to the lower number of bacilli. However, an accurate and timely diagnosis of the disease results in an improved efficacy of the given treatment. Besides the limitations of conventional methods, nowadays molecular diagnostic techniques have emerged as a major breakthrough for the early diagnosis of tuberculosis with high sensitivity and specificity. Alpha-crystallin is a dominantly expressed protein responsible for the long viability of the pathogen during the latent phase under certain stress conditions such as hypoxia and nitric oxide stress. Two other proteins—early secreted antigenic target-6 and culture filtrate protein-10—show high expression in the active infective phase of Mycobacterium tuberculosis. In this article, we focus on the different proteins expressed dominantly in latent/active tuberculosis, and which may be further used as prognostic biomarkers for diagnosing tuberculosis, both in latent and active phases. |
| first_indexed | 2024-12-21T09:53:01Z |
| format | Article |
| id | doaj.art-00a465ce8dce4d519477eabe47cb73b1 |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-12-21T09:53:01Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-00a465ce8dce4d519477eabe47cb73b12022-12-21T19:08:08ZengElsevierJournal of Orthopaedic Translation2214-031X2016-07-016C182610.1016/j.jot.2016.01.001Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosisNazia Rizvi0Ajai Singh1Manish Yadav2Syed Rizwan Hussain3Salma Siddiqui4Vineet Kumar5Sabir Ali6Avinash Agarwal7Department of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Orthopaedic Surgery, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaDepartment of Medicine, King George's Medical University, Lucknow 226 018, Uttar Pradesh, IndiaOsteoarticular tuberculosis constitutes about 3% of all tuberculosis cases. Early and accurate diagnosis of tuberculosis is a challenging problem especially in the case of osteoarticular tuberculosis owing to the lower number of bacilli. However, an accurate and timely diagnosis of the disease results in an improved efficacy of the given treatment. Besides the limitations of conventional methods, nowadays molecular diagnostic techniques have emerged as a major breakthrough for the early diagnosis of tuberculosis with high sensitivity and specificity. Alpha-crystallin is a dominantly expressed protein responsible for the long viability of the pathogen during the latent phase under certain stress conditions such as hypoxia and nitric oxide stress. Two other proteins—early secreted antigenic target-6 and culture filtrate protein-10—show high expression in the active infective phase of Mycobacterium tuberculosis. In this article, we focus on the different proteins expressed dominantly in latent/active tuberculosis, and which may be further used as prognostic biomarkers for diagnosing tuberculosis, both in latent and active phases.http://www.sciencedirect.com/science/article/pii/S2214031X16000140active phaseextrapulmonary tuberculosislatent-phase proteinsosteoarticular tuberculosis |
| spellingShingle | Nazia Rizvi Ajai Singh Manish Yadav Syed Rizwan Hussain Salma Siddiqui Vineet Kumar Sabir Ali Avinash Agarwal Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis Journal of Orthopaedic Translation active phase extrapulmonary tuberculosis latent-phase proteins osteoarticular tuberculosis |
| title | Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis |
| title_full | Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis |
| title_fullStr | Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis |
| title_full_unstemmed | Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis |
| title_short | Role of alpha-crystallin, early-secreted antigenic target 6-kDa protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis |
| title_sort | role of alpha crystallin early secreted antigenic target 6 kda protein and culture filtrate protein 10 as novel diagnostic markers in osteoarticular tuberculosis |
| topic | active phase extrapulmonary tuberculosis latent-phase proteins osteoarticular tuberculosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X16000140 |
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