Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
Forkhead box protein 3 (Foxp3+)-expressing regulatory T (Treg) cells are a unique CD4+T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.728783/full |
| _version_ | 1818584701521100800 |
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| author | Jingli Lu Jingli Lu Jingli Lu Yan Liang Yan Liang Yan Liang Haiyang Meng Haiyang Meng Haiyang Meng Ailing Zhang Ailing Zhang Ailing Zhang Junjie Zhao Junjie Zhao Junjie Zhao Chengliang Zhang |
| author_facet | Jingli Lu Jingli Lu Jingli Lu Yan Liang Yan Liang Yan Liang Haiyang Meng Haiyang Meng Haiyang Meng Ailing Zhang Ailing Zhang Ailing Zhang Junjie Zhao Junjie Zhao Junjie Zhao Chengliang Zhang |
| author_sort | Jingli Lu |
| collection | DOAJ |
| description | Forkhead box protein 3 (Foxp3+)-expressing regulatory T (Treg) cells are a unique CD4+T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore, alterations to the epigenetics and metabolism affect Treg cell development and function. Recent evidence reveals that altering the metabolic pathways and generation of metabolites can regulate the epigenetics of Treg cells. Specifically, some intermediates of cell metabolism can directly act as substrates or cofactors of epigenetic-modifying enzymes. Here, we describe the metabolic and epigenetic features during Treg cell development, and discuss how metabolites can contribute to epigenetic alterations of Treg cells, which affects Treg cell activation, differentiation, and function. |
| first_indexed | 2024-12-16T08:25:22Z |
| format | Article |
| id | doaj.art-00a50680031a480086c599c24d06469a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T08:25:22Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-00a50680031a480086c599c24d06469a2022-12-21T22:38:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.728783728783Metabolic Controls on Epigenetic Reprogramming in Regulatory T CellsJingli Lu0Jingli Lu1Jingli Lu2Yan Liang3Yan Liang4Yan Liang5Haiyang Meng6Haiyang Meng7Haiyang Meng8Ailing Zhang9Ailing Zhang10Ailing Zhang11Junjie Zhao12Junjie Zhao13Junjie Zhao14Chengliang Zhang15Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou, ChinaZhengzhou Key Laboratory of Clinical Mass Spectrometry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou, ChinaZhengzhou Key Laboratory of Clinical Mass Spectrometry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou, ChinaZhengzhou Key Laboratory of Clinical Mass Spectrometry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou, ChinaZhengzhou Key Laboratory of Clinical Mass Spectrometry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou, ChinaZhengzhou Key Laboratory of Clinical Mass Spectrometry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaForkhead box protein 3 (Foxp3+)-expressing regulatory T (Treg) cells are a unique CD4+T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore, alterations to the epigenetics and metabolism affect Treg cell development and function. Recent evidence reveals that altering the metabolic pathways and generation of metabolites can regulate the epigenetics of Treg cells. Specifically, some intermediates of cell metabolism can directly act as substrates or cofactors of epigenetic-modifying enzymes. Here, we describe the metabolic and epigenetic features during Treg cell development, and discuss how metabolites can contribute to epigenetic alterations of Treg cells, which affects Treg cell activation, differentiation, and function.https://www.frontiersin.org/articles/10.3389/fimmu.2021.728783/fullregulatory T cellsmetabolismepigeneticsimmune suppressionmetabolites |
| spellingShingle | Jingli Lu Jingli Lu Jingli Lu Yan Liang Yan Liang Yan Liang Haiyang Meng Haiyang Meng Haiyang Meng Ailing Zhang Ailing Zhang Ailing Zhang Junjie Zhao Junjie Zhao Junjie Zhao Chengliang Zhang Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells Frontiers in Immunology regulatory T cells metabolism epigenetics immune suppression metabolites |
| title | Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells |
| title_full | Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells |
| title_fullStr | Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells |
| title_full_unstemmed | Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells |
| title_short | Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells |
| title_sort | metabolic controls on epigenetic reprogramming in regulatory t cells |
| topic | regulatory T cells metabolism epigenetics immune suppression metabolites |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.728783/full |
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