Achievements in Thermosensitive Gelling Systems for Rectal Administration
Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. Howev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/11/5500 |
| _version_ | 1797532901727797248 |
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| author | Maria Bialik Marzena Kuras Marcin Sobczak Ewa Oledzka |
| author_facet | Maria Bialik Marzena Kuras Marcin Sobczak Ewa Oledzka |
| author_sort | Maria Bialik |
| collection | DOAJ |
| description | Rectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. However, this form of drug dosage often feels alien and uncomfortable to a patient, encouraging refusal. The limitations of conventional solid suppositories can be overcome by creating a thermosensitive liquid suppository. Unfortunately, there are currently only a few studies describing their use in therapy. However, recent trends indicate an increase in the development of this modern therapeutic system. This review introduces a novel rectal drug delivery system with the goal of summarising recent developments in thermosensitive liquid suppositories for analgesic, anticancer, antiemetic, antihypertensive, psychiatric, antiallergic, anaesthetic, antimalarial drugs and insulin. The report also presents the impact of various types of components and their concentration on the properties of this rectal dosage form. Further research into such formulations is certainly needed in order to meet the high demand for modern, efficient rectal gelling systems. Continued research and development in this field would undoubtedly further reveal the hidden potential of rectal drug delivery systems. |
| first_indexed | 2024-03-10T11:06:58Z |
| format | Article |
| id | doaj.art-00a70a827df1420c9e7d4e21b7b0a5ab |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T11:06:58Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-00a70a827df1420c9e7d4e21b7b0a5ab2023-11-21T21:01:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-012211550010.3390/ijms22115500Achievements in Thermosensitive Gelling Systems for Rectal AdministrationMaria Bialik0Marzena Kuras1Marcin Sobczak2Ewa Oledzka3Department of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, PolandDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, PolandDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, PolandDepartment of Biomaterials Chemistry, Chair of Analytical Chemistry and Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 02-097 Warsaw, PolandRectal drug delivery is an effective alternative to oral and parenteral treatments. This route allows for both local and systemic drug therapy. Traditional rectal dosage formulations have historically been used for localised treatments, including laxatives, hemorrhoid therapy and antipyretics. However, this form of drug dosage often feels alien and uncomfortable to a patient, encouraging refusal. The limitations of conventional solid suppositories can be overcome by creating a thermosensitive liquid suppository. Unfortunately, there are currently only a few studies describing their use in therapy. However, recent trends indicate an increase in the development of this modern therapeutic system. This review introduces a novel rectal drug delivery system with the goal of summarising recent developments in thermosensitive liquid suppositories for analgesic, anticancer, antiemetic, antihypertensive, psychiatric, antiallergic, anaesthetic, antimalarial drugs and insulin. The report also presents the impact of various types of components and their concentration on the properties of this rectal dosage form. Further research into such formulations is certainly needed in order to meet the high demand for modern, efficient rectal gelling systems. Continued research and development in this field would undoubtedly further reveal the hidden potential of rectal drug delivery systems.https://www.mdpi.com/1422-0067/22/11/5500rectal gelthermosensitive gelsolid suppositoryrectal drug deliverydrug delivery systemthermosensitive liquid suppository |
| spellingShingle | Maria Bialik Marzena Kuras Marcin Sobczak Ewa Oledzka Achievements in Thermosensitive Gelling Systems for Rectal Administration International Journal of Molecular Sciences rectal gel thermosensitive gel solid suppository rectal drug delivery drug delivery system thermosensitive liquid suppository |
| title | Achievements in Thermosensitive Gelling Systems for Rectal Administration |
| title_full | Achievements in Thermosensitive Gelling Systems for Rectal Administration |
| title_fullStr | Achievements in Thermosensitive Gelling Systems for Rectal Administration |
| title_full_unstemmed | Achievements in Thermosensitive Gelling Systems for Rectal Administration |
| title_short | Achievements in Thermosensitive Gelling Systems for Rectal Administration |
| title_sort | achievements in thermosensitive gelling systems for rectal administration |
| topic | rectal gel thermosensitive gel solid suppository rectal drug delivery drug delivery system thermosensitive liquid suppository |
| url | https://www.mdpi.com/1422-0067/22/11/5500 |
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