HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation
Acute graft versus host disease is a rare but deadly complication following liver transplantation. Author show here, upon screening a large cohort of liver transplanted patients and detailed immune phenotyping of samples from the 7 affected individuals and appropriate controls, that human T cell lym...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35111-w |
| _version_ | 1811190287861547008 |
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| author | Chuan Shen Yiyang Li Boqian Wang Zhipeng Zong Tianfei Lu Nokuzola Maboyi Yuxiao Deng Yongbing Qian Jianjun Zhang Xianting Ding Qiang Xia |
| author_facet | Chuan Shen Yiyang Li Boqian Wang Zhipeng Zong Tianfei Lu Nokuzola Maboyi Yuxiao Deng Yongbing Qian Jianjun Zhang Xianting Ding Qiang Xia |
| author_sort | Chuan Shen |
| collection | DOAJ |
| description | Acute graft versus host disease is a rare but deadly complication following liver transplantation. Author show here, upon screening a large cohort of liver transplanted patients and detailed immune phenotyping of samples from the 7 affected individuals and appropriate controls, that human T cell lymphotropic virus type I infection of donor immune cells appear to correlate with the occurrence of acute graft versus host disease. |
| first_indexed | 2024-04-11T14:48:50Z |
| format | Article |
| id | doaj.art-00a951543d814a338a0b05ca8cf71f47 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:48:50Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-00a951543d814a338a0b05ca8cf71f472022-12-22T04:17:33ZengNature PortfolioNature Communications2041-17232022-11-0113111210.1038/s41467-022-35111-wHTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantationChuan Shen0Yiyang Li1Boqian Wang2Zhipeng Zong3Tianfei Lu4Nokuzola Maboyi5Yuxiao Deng6Yongbing Qian7Jianjun Zhang8Xianting Ding9Qiang Xia10Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong UniversityDepartment of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityAbdominal Organ Transplantation Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong UniversityDepartment of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityDepartment of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityDepartment of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Institute for Personalized Medicine, School of Biomedical Engineering, Shanghai Jiao Tong UniversityDepartment of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityAcute graft versus host disease is a rare but deadly complication following liver transplantation. Author show here, upon screening a large cohort of liver transplanted patients and detailed immune phenotyping of samples from the 7 affected individuals and appropriate controls, that human T cell lymphotropic virus type I infection of donor immune cells appear to correlate with the occurrence of acute graft versus host disease.https://doi.org/10.1038/s41467-022-35111-w |
| spellingShingle | Chuan Shen Yiyang Li Boqian Wang Zhipeng Zong Tianfei Lu Nokuzola Maboyi Yuxiao Deng Yongbing Qian Jianjun Zhang Xianting Ding Qiang Xia HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation Nature Communications |
| title | HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation |
| title_full | HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation |
| title_fullStr | HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation |
| title_full_unstemmed | HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation |
| title_short | HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation |
| title_sort | htlv 1 infection of donor derived t cells might promote acute graft versus host disease following liver transplantation |
| url | https://doi.org/10.1038/s41467-022-35111-w |
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