The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis
Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs. Objectives We conducted a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Antimicrobial Resistance and Infection Control |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13756-023-01210-6 |
| _version_ | 1811175665132634112 |
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| author | Amir Hossein Hasanpour Mahdi Sepidarkish Abolfazl Mollalo Ali Ardekani Mustafa Almukhtar Amal Mechaal Seyed Reza Hosseini Masoumeh Bayani Mostafa Javanian Ali Rostami |
| author_facet | Amir Hossein Hasanpour Mahdi Sepidarkish Abolfazl Mollalo Ali Ardekani Mustafa Almukhtar Amal Mechaal Seyed Reza Hosseini Masoumeh Bayani Mostafa Javanian Ali Rostami |
| author_sort | Amir Hossein Hasanpour |
| collection | DOAJ |
| description | Abstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs. Objectives We conducted a worldwide systematic review and meta-analysis on the prevalence and risk factors of MRSA in ECCs. Methods We searched MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases and the gray literature sources for all studies published between January 1980 and December 2022 on the prevalence of MRSA in ECCs. A random-effects model was utilized to estimate pooled prevalence rates at 95% confidence intervals (CI). Moreover, the data were analyzed based on World Health Organization-defined regions, income, and human development index levels. Results In total, 119 studies, including 164,717 participants from 29 countries, were found eligible for meta-analysis. The pooled global prevalence of MRSA was 14.69% (95% CI 12.39–17.15%; 16,793/164,717). Male gender [prevalence ratio (PR) = 1.55; 95% CI 1.47–1.64], previous MRSA infection (PR = 3.71; 95% CI 3.44–4.01), prior use of antibiotics (PR = 1.97; 95% CI 1.83–2.12), hospitalized within the previous year (PR = 1.32; 95% CI 1.20–1.45), have had any wound (PR = 2.38; 95% CI 2.23–2.55), have used urinary catheter (PR = 2.24; 95% CI 2.06–2.43), have used any medical device (PR = 1.78; 95% CI 1.66–1.91), and those with diabetes (PR = 1.55; CI 1.43–1.67) were more likely to be colonized by MRSA than other patients. Conclusion Screening programs and preventive measures should target MRSA in ECCs due to the high global prevalence rates. |
| first_indexed | 2024-04-10T19:40:29Z |
| format | Article |
| id | doaj.art-00a995df127448c88f28754a491914a7 |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-04-10T19:40:29Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-00a995df127448c88f28754a491914a72023-01-29T12:22:15ZengBMCAntimicrobial Resistance and Infection Control2047-29942023-01-0112111110.1186/s13756-023-01210-6The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysisAmir Hossein Hasanpour0Mahdi Sepidarkish1Abolfazl Mollalo2Ali Ardekani3Mustafa Almukhtar4Amal Mechaal5Seyed Reza Hosseini6Masoumeh Bayani7Mostafa Javanian8Ali Rostami9Student Research Committee, Babol University of Medical SciencesDepartment of Biostatistics and Epidemiology, School of Public Health, Babol University of Medical SciencesDepartment of Public Health and Prevention Science, School of Health Sciences, Baldwin Wallace UniversitySchool of Medicine, Shiraz University of Medical SciencesHarlem Medical CenterDepartment of Hematopoietic Biology and Malignancy, The University of Texas Md Anderson Cancer CenterSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical SciencesSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical SciencesAbstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a difficult to treat infection, particularly in residents of elderly care centers (ECCs). Despite the substantial burden of MRSA, an inadequate number of studies have analyzed MRSA prevalence in ECCs. Objectives We conducted a worldwide systematic review and meta-analysis on the prevalence and risk factors of MRSA in ECCs. Methods We searched MEDLINE/PubMed, EMBASE, Web of Science, and Scopus databases and the gray literature sources for all studies published between January 1980 and December 2022 on the prevalence of MRSA in ECCs. A random-effects model was utilized to estimate pooled prevalence rates at 95% confidence intervals (CI). Moreover, the data were analyzed based on World Health Organization-defined regions, income, and human development index levels. Results In total, 119 studies, including 164,717 participants from 29 countries, were found eligible for meta-analysis. The pooled global prevalence of MRSA was 14.69% (95% CI 12.39–17.15%; 16,793/164,717). Male gender [prevalence ratio (PR) = 1.55; 95% CI 1.47–1.64], previous MRSA infection (PR = 3.71; 95% CI 3.44–4.01), prior use of antibiotics (PR = 1.97; 95% CI 1.83–2.12), hospitalized within the previous year (PR = 1.32; 95% CI 1.20–1.45), have had any wound (PR = 2.38; 95% CI 2.23–2.55), have used urinary catheter (PR = 2.24; 95% CI 2.06–2.43), have used any medical device (PR = 1.78; 95% CI 1.66–1.91), and those with diabetes (PR = 1.55; CI 1.43–1.67) were more likely to be colonized by MRSA than other patients. Conclusion Screening programs and preventive measures should target MRSA in ECCs due to the high global prevalence rates.https://doi.org/10.1186/s13756-023-01210-6Methicillin-resistant Staphylococcus aureusResidential facilitiesNursing homesLong-term careSystematic review |
| spellingShingle | Amir Hossein Hasanpour Mahdi Sepidarkish Abolfazl Mollalo Ali Ardekani Mustafa Almukhtar Amal Mechaal Seyed Reza Hosseini Masoumeh Bayani Mostafa Javanian Ali Rostami The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis Antimicrobial Resistance and Infection Control Methicillin-resistant Staphylococcus aureus Residential facilities Nursing homes Long-term care Systematic review |
| title | The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis |
| title_full | The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis |
| title_fullStr | The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis |
| title_full_unstemmed | The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis |
| title_short | The global prevalence of methicillin-resistant Staphylococcus aureus colonization in residents of elderly care centers: a systematic review and meta-analysis |
| title_sort | global prevalence of methicillin resistant staphylococcus aureus colonization in residents of elderly care centers a systematic review and meta analysis |
| topic | Methicillin-resistant Staphylococcus aureus Residential facilities Nursing homes Long-term care Systematic review |
| url | https://doi.org/10.1186/s13756-023-01210-6 |
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