Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea

Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea

Background: Patients with obstructive sleep apnea (OSA) experience recurrent hypoxemic events with a frequency sometimes exceeding 60 events/h. These episodic events induce downstream transient hypoxia in the parenchymal tissue of all organs, thereby eliciting the pathological consequences of OSA. W...

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Bibliographic Details
Main Authors: Alicia Jurado, Anna Ulldemolins, Helena Lluís, Xavier Gasull, Núria Gavara, Raimon Sunyer, Jorge Otero, David Gozal, Isaac Almendros, Ramon Farré
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
obstructive sleep apnea
hypoxia
cell culture
hydrogels
tissue slice
3D culture
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1081345/full

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