Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage
Abstract After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study s...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-024-02368-w |
| _version_ | 1797246970975223808 |
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| author | Xiaolong Tang Xinyu Yang Yamei Yu Miaojing Wu Yuanyuan Li Zhe Zhang Guangyu Jia Qi Wang Wei Tu Ye Wang Xingen Zhu Shiyong Li |
| author_facet | Xiaolong Tang Xinyu Yang Yamei Yu Miaojing Wu Yuanyuan Li Zhe Zhang Guangyu Jia Qi Wang Wei Tu Ye Wang Xingen Zhu Shiyong Li |
| author_sort | Xiaolong Tang |
| collection | DOAJ |
| description | Abstract After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH. |
| first_indexed | 2024-04-24T19:51:16Z |
| format | Article |
| id | doaj.art-00a9fa935418484b88195acb2c51076e |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-24T19:51:16Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-00a9fa935418484b88195acb2c51076e2024-03-24T12:32:39ZengBMCJournal of Nanobiotechnology1477-31552024-03-0122111410.1186/s12951-024-02368-wCarbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral HemorrhageXiaolong Tang0Xinyu Yang1Yamei Yu2Miaojing Wu3Yuanyuan Li4Zhe Zhang5Guangyu Jia6Qi Wang7Wei Tu8Ye Wang9Xingen Zhu10Shiyong Li11Institute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityInstitute of Neuroscience, Jiangxi Medical College, Nanchang UniversityAbstract After intracerebral hemorrhage (ICH) occurs, the overproduction of reactive oxygen species (ROS) and iron ion overload are the leading causes of secondary damage. Removing excess iron ions and ROS in the meningeal system can effectively alleviate the secondary damage after ICH. This study synthesized ginsenoside Rb1 carbon quantum dots (RBCQDs) using ginsenoside Rb1 and ethylenediamine via a hydrothermal method. RBCQDs exhibit potent capabilities in scavenging ABTS + free radicals and iron ions in solution. After intrathecal injection, the distribution of RBCQDs is predominantly localized in the subarachnoid space. RBCQDs can eliminate ROS and chelate iron ions within the meningeal system. Treatment with RBCQDs significantly improves blood flow in the meningeal system, effectively protecting dying neurons, improving neurological function, and providing a new therapeutic approach for the clinical treatment of ICH.https://doi.org/10.1186/s12951-024-02368-wCarbon quantum dotsGinsenoside Rb1Reactive oxygen speciesiron overloadOxidative stress |
| spellingShingle | Xiaolong Tang Xinyu Yang Yamei Yu Miaojing Wu Yuanyuan Li Zhe Zhang Guangyu Jia Qi Wang Wei Tu Ye Wang Xingen Zhu Shiyong Li Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage Journal of Nanobiotechnology Carbon quantum dots Ginsenoside Rb1 Reactive oxygen species iron overload Oxidative stress |
| title | Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage |
| title_full | Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage |
| title_fullStr | Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage |
| title_full_unstemmed | Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage |
| title_short | Carbon quantum dots of ginsenoside Rb1 for application in a mouse model of intracerebral Hemorrhage |
| title_sort | carbon quantum dots of ginsenoside rb1 for application in a mouse model of intracerebral hemorrhage |
| topic | Carbon quantum dots Ginsenoside Rb1 Reactive oxygen species iron overload Oxidative stress |
| url | https://doi.org/10.1186/s12951-024-02368-w |
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