Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA)
BackgroundRecent studies have failed to establish a causal relationship between high‐density lipoprotein cholesterol levels (HDL‐C) and cardiovascular disease (CVD), shifting focus to other HDL measures. We previously reported that smaller/denser HDL levels are protective against cerebrovascular dis...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.115.002977 |
| _version_ | 1819178626363424768 |
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| author | Daniel Seung Kim Yatong K. Li Griffith A. Bell Amber A. Burt Tomas Vaisar Patrick M. Hutchins Clement E. Furlong James D. Otvos Joseph F. Polak Martinson Kweku Arnan Joel D. Kaufman Robyn L. McClelland W. T. Longstreth Gail P. Jarvik |
| author_facet | Daniel Seung Kim Yatong K. Li Griffith A. Bell Amber A. Burt Tomas Vaisar Patrick M. Hutchins Clement E. Furlong James D. Otvos Joseph F. Polak Martinson Kweku Arnan Joel D. Kaufman Robyn L. McClelland W. T. Longstreth Gail P. Jarvik |
| author_sort | Daniel Seung Kim |
| collection | DOAJ |
| description | BackgroundRecent studies have failed to establish a causal relationship between high‐density lipoprotein cholesterol levels (HDL‐C) and cardiovascular disease (CVD), shifting focus to other HDL measures. We previously reported that smaller/denser HDL levels are protective against cerebrovascular disease. This study sought to determine which of small+medium HDL particle concentration (HDL‐P) or large HDL‐P was more strongly associated with carotid intima‐media thickening (cIMT) in an ethnically diverse cohort. Methods and ResultsIn cross‐sectional analyses of participants from the Multi Ethnic Study of Atherosclerosis (MESA), we evaluated the associations of nuclear magnetic resonance spectroscopy–measured small+medium versus large HDL‐P with cIMT measured in the common and internal carotid arteries, through linear regression. After adjustment for CVD confounders, low‐density lipoprotein cholesterol (LDL‐C), HDL‐C, and small+medium HDL‐P remained significantly and inversely associated with common (coefficient=−1.46 μm; P=0.00037; n=6512) and internal cIMT (coefficient=−3.82 μm; P=0.0051; n=6418) after Bonferroni correction for 4 independent tests (threshold for significance=0.0125; α=0.05/4). Large HDL‐P was significantly and inversely associated with both cIMT outcomes before HDL‐C adjustment; however, after adjustment for HDL‐C, the association of large HDL‐P with both common (coefficient=1.55 μm; P=0.30; n=6512) and internal cIMT (coefficient=4.84 μm; P=0.33; n=6418) was attenuated. In a separate sample of 126 men, small/medium HDL‐P was more strongly correlated with paraoxonase 1 activity (rp=0.32; P=0.00023) as compared to both total HDL‐P (rp=0.27; P=0.0024) and large HDL‐P (rp=0.02; P=0.41) measures. ConclusionsSmall+medium HDL‐P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL‐P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding. |
| first_indexed | 2024-12-22T21:45:32Z |
| format | Article |
| id | doaj.art-00ac7c79b79f4973a76b745fb364f498 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T21:45:32Z |
| publishDate | 2016-05-01 |
| publisher | Wiley |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-00ac7c79b79f4973a76b745fb364f4982022-12-21T18:11:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-05-015510.1161/JAHA.115.002977Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA)Daniel Seung Kim0Yatong K. Li1Griffith A. Bell2Amber A. Burt3Tomas Vaisar4Patrick M. Hutchins5Clement E. Furlong6James D. Otvos7Joseph F. Polak8Martinson Kweku Arnan9Joel D. Kaufman10Robyn L. McClelland11W. T. Longstreth12Gail P. Jarvik13Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WADepartment of Biostatistics, University of Washington School of Public Health, Seattle, WADepartment of Epidemiology, University of Washington School of Public Health, Seattle, WADivision of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WADivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WADivision of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WADivision of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WALabCorp, Raleigh, NCDepartment of Radiology, Tufts University School of Medicine, Boston, MADepartment of Neurology, University of Washington School of Medicine, Seattle, WADivision of General Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, WADepartment of Biostatistics, University of Washington School of Public Health, Seattle, WADepartment of Neurology, Wake Forest School of Medicine, Winston‐Salem, NCDivision of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle, WABackgroundRecent studies have failed to establish a causal relationship between high‐density lipoprotein cholesterol levels (HDL‐C) and cardiovascular disease (CVD), shifting focus to other HDL measures. We previously reported that smaller/denser HDL levels are protective against cerebrovascular disease. This study sought to determine which of small+medium HDL particle concentration (HDL‐P) or large HDL‐P was more strongly associated with carotid intima‐media thickening (cIMT) in an ethnically diverse cohort. Methods and ResultsIn cross‐sectional analyses of participants from the Multi Ethnic Study of Atherosclerosis (MESA), we evaluated the associations of nuclear magnetic resonance spectroscopy–measured small+medium versus large HDL‐P with cIMT measured in the common and internal carotid arteries, through linear regression. After adjustment for CVD confounders, low‐density lipoprotein cholesterol (LDL‐C), HDL‐C, and small+medium HDL‐P remained significantly and inversely associated with common (coefficient=−1.46 μm; P=0.00037; n=6512) and internal cIMT (coefficient=−3.82 μm; P=0.0051; n=6418) after Bonferroni correction for 4 independent tests (threshold for significance=0.0125; α=0.05/4). Large HDL‐P was significantly and inversely associated with both cIMT outcomes before HDL‐C adjustment; however, after adjustment for HDL‐C, the association of large HDL‐P with both common (coefficient=1.55 μm; P=0.30; n=6512) and internal cIMT (coefficient=4.84 μm; P=0.33; n=6418) was attenuated. In a separate sample of 126 men, small/medium HDL‐P was more strongly correlated with paraoxonase 1 activity (rp=0.32; P=0.00023) as compared to both total HDL‐P (rp=0.27; P=0.0024) and large HDL‐P (rp=0.02; P=0.41) measures. ConclusionsSmall+medium HDL‐P is significantly and inversely correlated with cIMT measurements. Correlation of small+medium HDL‐P with cardioprotective paraoxonase 1 activity may reflect a functional aspect of HDL responsible for this finding.https://www.ahajournals.org/doi/10.1161/JAHA.115.002977antioxidantcarotid intima media thickeningcerebrovascular diseasehigh‐density lipoprotein cholesterolhigh‐density lipoprotein particle concentrationparaoxonase 1 |
| spellingShingle | Daniel Seung Kim Yatong K. Li Griffith A. Bell Amber A. Burt Tomas Vaisar Patrick M. Hutchins Clement E. Furlong James D. Otvos Joseph F. Polak Martinson Kweku Arnan Joel D. Kaufman Robyn L. McClelland W. T. Longstreth Gail P. Jarvik Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease antioxidant carotid intima media thickening cerebrovascular disease high‐density lipoprotein cholesterol high‐density lipoprotein particle concentration paraoxonase 1 |
| title | Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) |
| title_full | Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) |
| title_fullStr | Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) |
| title_full_unstemmed | Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) |
| title_short | Concentration of Smaller High‐Density Lipoprotein Particle (HDL‐P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: The Multi Ethnic Study of Atherosclerosis (MESA) |
| title_sort | concentration of smaller high density lipoprotein particle hdl p is inversely correlated with carotid intima media thickening after confounder adjustment the multi ethnic study of atherosclerosis mesa |
| topic | antioxidant carotid intima media thickening cerebrovascular disease high‐density lipoprotein cholesterol high‐density lipoprotein particle concentration paraoxonase 1 |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.115.002977 |
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