Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer
Objective To analyze the factors affecting postoperative first serum prostate specific antigen (PSA) level at 6 weeks in patients receiving radical prostatectomy (RP) for prostate cancer. Methods The clinicopathological data were collected retrospectively from 251 patients undergoing RP for prostate...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2019-08-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/201903200.htm |
| _version_ | 1818609575800078336 |
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| author | ZHANG Jingqi ZHOU Xiaozhou JI Huixiang ZHENG Ji CHEN Zhiwen |
| author_facet | ZHANG Jingqi ZHOU Xiaozhou JI Huixiang ZHENG Ji CHEN Zhiwen |
| author_sort | ZHANG Jingqi |
| collection | DOAJ |
| description | Objective To analyze the factors affecting postoperative first serum prostate specific antigen (PSA) level at 6 weeks in patients receiving radical prostatectomy (RP) for prostate cancer. Methods The clinicopathological data were collected retrospectively from 251 patients undergoing RP for prostate cancer in our department between January, 2014 and May, 2018. According to postoperative first serum PSA levels at 6-8 weeks for assessing biochemical recurrence (with 0.2 ng/mL as the cut-off PSA level), the patients were divided into PSA < 0.2 ng/mL group and PSA≥0.2 ng/mL group, and univariate analysis and multivariate Logistic regression analysis was performed to identify the factors affecting first serum PSA level after RP. Results The two groups of patients with prostate cancer showed significant differences in BMI, history of preoperative electric resection, preoperative PSA level, postoperative Gleason score, pathological T staging, lymph node dissection, and the number of dissected lymph nodes (P < 0.05). The results of multivariate Logistic regression analysis showed that BMI, preoperative PSA level, postoperative Gleason score and pathological T staging were all independent risk factors affecting postoperative first serum PSA level. In the 153 patients with lymph node dissection, BMI, preoperative PSA level, postoperative Gleason score, pathological T staging, lymph node positivity and the number of positive lymph nodes differed significantly between the patients with postoperative PSA level < 0.2 ng/mL at 6 weeks and those with higher PSA levels (P < 0.05). Multivariate Logistic regression analysis showed that preoperative PSA level and lymph node positivity were independent risk factors that affected the postoperative first serum PSA level. Conclusion BMI, preoperative PSA level, postoperative Gleason score and pathologic T staging are all independent risk factors affecting the postoperative first serum PSA level in prostate cancer patients; In patients with lymph node dissection, preoperative PSA level and lymph node positivity are independent risk factors affecting the postoperative first serum PSA level. |
| first_indexed | 2024-12-16T15:00:43Z |
| format | Article |
| id | doaj.art-00acf776eaee43f996fa84ad855e288c |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-16T15:00:43Z |
| publishDate | 2019-08-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-00acf776eaee43f996fa84ad855e288c2022-12-21T22:27:18ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042019-08-0141161590159510.16016/j.1000-5404.201903200Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancerZHANG Jingqi0ZHOU Xiaozhou1JI Huixiang2ZHENG Ji3CHEN Zhiwen4Institute of Urology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaInstitute of Urology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaInstitute of Urology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaInstitute of Urology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaInstitute of Urology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, ChinaObjective To analyze the factors affecting postoperative first serum prostate specific antigen (PSA) level at 6 weeks in patients receiving radical prostatectomy (RP) for prostate cancer. Methods The clinicopathological data were collected retrospectively from 251 patients undergoing RP for prostate cancer in our department between January, 2014 and May, 2018. According to postoperative first serum PSA levels at 6-8 weeks for assessing biochemical recurrence (with 0.2 ng/mL as the cut-off PSA level), the patients were divided into PSA < 0.2 ng/mL group and PSA≥0.2 ng/mL group, and univariate analysis and multivariate Logistic regression analysis was performed to identify the factors affecting first serum PSA level after RP. Results The two groups of patients with prostate cancer showed significant differences in BMI, history of preoperative electric resection, preoperative PSA level, postoperative Gleason score, pathological T staging, lymph node dissection, and the number of dissected lymph nodes (P < 0.05). The results of multivariate Logistic regression analysis showed that BMI, preoperative PSA level, postoperative Gleason score and pathological T staging were all independent risk factors affecting postoperative first serum PSA level. In the 153 patients with lymph node dissection, BMI, preoperative PSA level, postoperative Gleason score, pathological T staging, lymph node positivity and the number of positive lymph nodes differed significantly between the patients with postoperative PSA level < 0.2 ng/mL at 6 weeks and those with higher PSA levels (P < 0.05). Multivariate Logistic regression analysis showed that preoperative PSA level and lymph node positivity were independent risk factors that affected the postoperative first serum PSA level. Conclusion BMI, preoperative PSA level, postoperative Gleason score and pathologic T staging are all independent risk factors affecting the postoperative first serum PSA level in prostate cancer patients; In patients with lymph node dissection, preoperative PSA level and lymph node positivity are independent risk factors affecting the postoperative first serum PSA level.http://aammt.tmmu.edu.cn/Upload/rhtml/201903200.htmradical prostatectomyprostate cancerbiochemical recurrencelogistic regression analysis |
| spellingShingle | ZHANG Jingqi ZHOU Xiaozhou JI Huixiang ZHENG Ji CHEN Zhiwen Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer Di-san junyi daxue xuebao radical prostatectomy prostate cancer biochemical recurrence logistic regression analysis |
| title | Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer |
| title_full | Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer |
| title_fullStr | Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer |
| title_full_unstemmed | Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer |
| title_short | Analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer |
| title_sort | analysis of factors affecting first serum prostate specific antigen level after radical prostatectomy for prostate cancer |
| topic | radical prostatectomy prostate cancer biochemical recurrence logistic regression analysis |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/201903200.htm |
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