Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods
<p><strong>Background</strong>: Neuroblastoma is a malignant tumor of the sympathetic nervous system, representning about 5 % of all childhood malignancies. The aim of our study was to compare the survival of neuroblastoma patients treated in Slovenia in two time periods, 1994–2007...
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| Format: | Article |
| Language: | English |
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Slovenian Medical Association
2014-04-01
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| Series: | Zdravniški Vestnik |
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| Online Access: | http://vestnik.szd.si/index.php/ZdravVest/article/view/1133 |
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| author | Jasna Perković Katja Petruša Mojca Berlec Lorna Zadravec-Zaletel Berta Jereb |
| author_facet | Jasna Perković Katja Petruša Mojca Berlec Lorna Zadravec-Zaletel Berta Jereb |
| author_sort | Jasna Perković |
| collection | DOAJ |
| description | <p><strong>Background</strong>: Neuroblastoma is a malignant tumor of the sympathetic nervous system, representning about 5 % of all childhood malignancies. The aim of our study was to compare the survival of neuroblastoma patients treated in Slovenia in two time periods, 1994–2007 and 1980–1993, and analyze the influence of different factors on survival. The hypothesis was that there has been an improvement in the survival of neuroblastoma patients treated after 1994.</p><p><strong>Methods</strong>: Seventy-eight neuroblastoma patients, treated at the Department of Pediatrics and at the Institute of Oncology in Ljubljana in the period 1980–2007 were included in the retrospective study. The list of patients and their basic data were collected from the Cancer Registry of Slovenia. Furtjer data about the patients, tumor characteristics and treatment were collected from patients’ records.</p><p><strong>Results</strong>: Thirty-nine (50 %) out of seventy-eight neuroblastoma patients included in the study are alive; of the 39 (50 %) dead, 23 (29.5 %) died during primary tumor treatment, 15 (19.2 %) died after recurrent disease, and the cause of death in one (1.3 %) patient remained unknown. The survival rates according to stage of disease, site of primary tumor and tumor size have improved in children treated after 1994, as compared to those treated before 1994. The most important factors influencing the prognosis in both time periods were stage of disease, patients’ age and tumor size at diagnosis while there was no statistical difference in survival according to age at diagnosis and the extent of surgery.</p><p><strong>Conclusions</strong>: The retrospective study confirmed our hypothesis that the survival of our patients treated after 1994 was better than the survival of those treated before. The most important prognostic factors in both periods were stage of the disease, age at diagnosis and tumor size.</p> |
| first_indexed | 2024-12-14T00:13:03Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1318-0347 1581-0224 |
| language | English |
| last_indexed | 2024-12-14T00:13:03Z |
| publishDate | 2014-04-01 |
| publisher | Slovenian Medical Association |
| record_format | Article |
| series | Zdravniški Vestnik |
| spelling | doaj.art-00b00803e31442bd8db4555ca4c8aab12022-12-21T23:25:40ZengSlovenian Medical AssociationZdravniški Vestnik1318-03471581-02242014-04-01833880Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periodsJasna Perković0Katja Petruša1Mojca Berlec2Lorna Zadravec-Zaletel3Berta Jereb4Onkološki inštitut v Ljubljani, Zaloška cesta 2, 1000 Ljubljana Dobje 13, Zasip, 4260 BledOnkološki inštitut v Ljubljani, Zaloška cesta 2, 1000 LjubljanaOnkološki inštitut v Ljubljani, Zaloška cesta 2, 1000 LjubljanaOnkološki inštitut v Ljubljani, Zaloška cesta 2, 1000 LjubljanaOnkološki inštitut v Ljubljani, Zaloška cesta 2, 1000 Ljubljana<p><strong>Background</strong>: Neuroblastoma is a malignant tumor of the sympathetic nervous system, representning about 5 % of all childhood malignancies. The aim of our study was to compare the survival of neuroblastoma patients treated in Slovenia in two time periods, 1994–2007 and 1980–1993, and analyze the influence of different factors on survival. The hypothesis was that there has been an improvement in the survival of neuroblastoma patients treated after 1994.</p><p><strong>Methods</strong>: Seventy-eight neuroblastoma patients, treated at the Department of Pediatrics and at the Institute of Oncology in Ljubljana in the period 1980–2007 were included in the retrospective study. The list of patients and their basic data were collected from the Cancer Registry of Slovenia. Furtjer data about the patients, tumor characteristics and treatment were collected from patients’ records.</p><p><strong>Results</strong>: Thirty-nine (50 %) out of seventy-eight neuroblastoma patients included in the study are alive; of the 39 (50 %) dead, 23 (29.5 %) died during primary tumor treatment, 15 (19.2 %) died after recurrent disease, and the cause of death in one (1.3 %) patient remained unknown. The survival rates according to stage of disease, site of primary tumor and tumor size have improved in children treated after 1994, as compared to those treated before 1994. The most important factors influencing the prognosis in both time periods were stage of disease, patients’ age and tumor size at diagnosis while there was no statistical difference in survival according to age at diagnosis and the extent of surgery.</p><p><strong>Conclusions</strong>: The retrospective study confirmed our hypothesis that the survival of our patients treated after 1994 was better than the survival of those treated before. The most important prognostic factors in both periods were stage of the disease, age at diagnosis and tumor size.</p>http://vestnik.szd.si/index.php/ZdravVest/article/view/1133childneuroblastomasurvivalprognostic factors |
| spellingShingle | Jasna Perković Katja Petruša Mojca Berlec Lorna Zadravec-Zaletel Berta Jereb Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods Zdravniški Vestnik child neuroblastoma survival prognostic factors |
| title | Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods |
| title_full | Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods |
| title_fullStr | Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods |
| title_full_unstemmed | Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods |
| title_short | Survival of children with neuroblastoma treated at the Institute of oncology in Ljubljana in two periods |
| title_sort | survival of children with neuroblastoma treated at the institute of oncology in ljubljana in two periods |
| topic | child neuroblastoma survival prognostic factors |
| url | http://vestnik.szd.si/index.php/ZdravVest/article/view/1133 |
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