Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Hexokinase 2 Depletion Confers Sensitization to Metformin and Inhibits Glycolysis in Lung Squamous Cell Carcinoma

Lung squamous cell carcinomas (SCCs) are highly aggressive tumors, and there is currently no effective targeted therapy owing to the lack of specific mutation targets. Compared with lung adenocarcinoma (ADCs), lung SCCs reportedly utilized higher levels of glucose metabolism to meet the anabolic and...

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Bibliographic Details
Main Authors: Wenzheng Guo, Yanbin Kuang, Jingjing Wu, Donghua Wen, Aiping Zhou, Yueling Liao, Hongyong Song, Dongliang Xu, Tong Wang, Bo Jing, Kaimi Li, Min Hu, Jing Ling, Qi Wang, Wenjuan Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
hexokinase 2
glycolysis
metformin
lung squamous cell carcinoma
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00052/full

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