Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), a class III histone deacetylase, is associated with the regulation of various pathophysiological processes, including inflamm...

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Bibliographic Details
Main Authors: Jiangnan Pei, Zhenzhen Liu, Chengjie Wang, Nan Chu, Lei Liu, Yao Tang, Haiyan Liu, Qianqian Xiang, Haidong Cheng, Mingqing Li, Weirong Gu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomolecules
Subjects:
progesterone
pre-eclampsia
SIRT1
pre-eclampsia-like mice
SRT2104
metformin
Online Access:https://www.mdpi.com/2218-273X/12/3/422

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