CDK4, a new metabolic sensor that antagonizes AMPK
Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-09-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1409862 |
| _version_ | 1797677120994934784 |
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| author | L. Fajas I. C. Lopez-Mejia |
| author_facet | L. Fajas I. C. Lopez-Mejia |
| author_sort | L. Fajas |
| collection | DOAJ |
| description | Cyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase). |
| first_indexed | 2024-03-11T22:40:23Z |
| format | Article |
| id | doaj.art-00b3e7b7905e46d5970761a763cc1b21 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:23Z |
| publishDate | 2018-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-00b3e7b7905e46d5970761a763cc1b212023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-09-015510.1080/23723556.2017.14098621409862CDK4, a new metabolic sensor that antagonizes AMPKL. Fajas0I. C. Lopez-Mejia1Center for Integrative Genomics, University of LausanneCenter for Integrative Genomics, University of LausanneCyclin-dependent kinase 4 (CDK4) is a positive regulator of cell cycle progression, however, there is growing evidence demonstrating that its function exceeds the control of cell division. Here we show that CDK4 is an important regulator of cellular substrate utilization through direct inhibition of the metabolic regulator AMPK (AMP-activated protein kinase).http://dx.doi.org/10.1080/23723556.2017.1409862cell cyclemetabolismcdk4fatty acid oxidationampktumor metabolism |
| spellingShingle | L. Fajas I. C. Lopez-Mejia CDK4, a new metabolic sensor that antagonizes AMPK Molecular & Cellular Oncology cell cycle metabolism cdk4 fatty acid oxidation ampk tumor metabolism |
| title | CDK4, a new metabolic sensor that antagonizes AMPK |
| title_full | CDK4, a new metabolic sensor that antagonizes AMPK |
| title_fullStr | CDK4, a new metabolic sensor that antagonizes AMPK |
| title_full_unstemmed | CDK4, a new metabolic sensor that antagonizes AMPK |
| title_short | CDK4, a new metabolic sensor that antagonizes AMPK |
| title_sort | cdk4 a new metabolic sensor that antagonizes ampk |
| topic | cell cycle metabolism cdk4 fatty acid oxidation ampk tumor metabolism |
| url | http://dx.doi.org/10.1080/23723556.2017.1409862 |
| work_keys_str_mv | AT lfajas cdk4anewmetabolicsensorthatantagonizesampk AT iclopezmejia cdk4anewmetabolicsensorthatantagonizesampk |