Lectins as potential tools for cancer biomarker discovery from extracellular vesicles
Abstract Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be used to “target” EVs to specific cells. Cancer is associated with alterations to c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-023-00520-6 |
| _version_ | 1827709216555532288 |
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| author | Md. Khirul Islam Misba Khan Kamlesh Gidwani Kenneth W. Witwer Urpo Lamminmäki Janne Leivo |
| author_facet | Md. Khirul Islam Misba Khan Kamlesh Gidwani Kenneth W. Witwer Urpo Lamminmäki Janne Leivo |
| author_sort | Md. Khirul Islam |
| collection | DOAJ |
| description | Abstract Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be used to “target” EVs to specific cells. Cancer is associated with alterations to cellular and EV glycosylation patterns, and the surface of EVs is enriched with glycan moieties. Glycoconjugates of EVs play versatile roles in cancer including modulating immune response, affecting tumor cell behavior and site of metastasis and as such, paving the way for the development of innovative diagnostic tools and novel therapies. Entities that recognize specific glycans, such as lectins, may thus be powerful tools to discover and detect novel cancer biomarkers. Indeed, the past decade has seen a constant increase in the number of published articles on lectin-based strategies for the detection of EV glycans. This review explores the roles of EV glycosylation in cancer and cancer-related applications. Furthermore, this review summarizes the potential of lectins and lectin-based methods for screening, targeting, separation, and possible identification of improved biomarkers from the surface of EVs. |
| first_indexed | 2024-03-10T17:17:48Z |
| format | Article |
| id | doaj.art-00b473a79049445b8467c42916db3639 |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-03-10T17:17:48Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-00b473a79049445b8467c42916db36392023-11-20T10:25:02ZengBMCBiomarker Research2050-77712023-09-0111112210.1186/s40364-023-00520-6Lectins as potential tools for cancer biomarker discovery from extracellular vesiclesMd. Khirul Islam0Misba Khan1Kamlesh Gidwani2Kenneth W. Witwer3Urpo Lamminmäki4Janne Leivo5Department of Life Technologies, Division of Biotechnology, University of TurkuDepartment of Life Technologies, Division of Biotechnology, University of TurkuDepartment of Life Technologies, Division of Biotechnology, University of TurkuDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of MedicineDepartment of Life Technologies, Division of Biotechnology, University of TurkuDepartment of Life Technologies, Division of Biotechnology, University of TurkuAbstract Extracellular vesicles (EVs) have considerable potential as diagnostic, prognostic, and therapeutic agents, in large part because molecular patterns on the EV surface betray the cell of origin and may also be used to “target” EVs to specific cells. Cancer is associated with alterations to cellular and EV glycosylation patterns, and the surface of EVs is enriched with glycan moieties. Glycoconjugates of EVs play versatile roles in cancer including modulating immune response, affecting tumor cell behavior and site of metastasis and as such, paving the way for the development of innovative diagnostic tools and novel therapies. Entities that recognize specific glycans, such as lectins, may thus be powerful tools to discover and detect novel cancer biomarkers. Indeed, the past decade has seen a constant increase in the number of published articles on lectin-based strategies for the detection of EV glycans. This review explores the roles of EV glycosylation in cancer and cancer-related applications. Furthermore, this review summarizes the potential of lectins and lectin-based methods for screening, targeting, separation, and possible identification of improved biomarkers from the surface of EVs.https://doi.org/10.1186/s40364-023-00520-6Extracellular vesiclesGlycosylationLectinGlycanLectin assayCancer biomarker |
| spellingShingle | Md. Khirul Islam Misba Khan Kamlesh Gidwani Kenneth W. Witwer Urpo Lamminmäki Janne Leivo Lectins as potential tools for cancer biomarker discovery from extracellular vesicles Biomarker Research Extracellular vesicles Glycosylation Lectin Glycan Lectin assay Cancer biomarker |
| title | Lectins as potential tools for cancer biomarker discovery from extracellular vesicles |
| title_full | Lectins as potential tools for cancer biomarker discovery from extracellular vesicles |
| title_fullStr | Lectins as potential tools for cancer biomarker discovery from extracellular vesicles |
| title_full_unstemmed | Lectins as potential tools for cancer biomarker discovery from extracellular vesicles |
| title_short | Lectins as potential tools for cancer biomarker discovery from extracellular vesicles |
| title_sort | lectins as potential tools for cancer biomarker discovery from extracellular vesicles |
| topic | Extracellular vesicles Glycosylation Lectin Glycan Lectin assay Cancer biomarker |
| url | https://doi.org/10.1186/s40364-023-00520-6 |
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