The role of retinoic acid signaling in starfish metamorphosis
Abstract Background Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA si...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | EvoDevo |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13227-018-0098-x |
| _version_ | 1819132811167137792 |
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| author | Shumpei Yamakawa Yoshiaki Morino Masanao Honda Hiroshi Wada |
| author_facet | Shumpei Yamakawa Yoshiaki Morino Masanao Honda Hiroshi Wada |
| author_sort | Shumpei Yamakawa |
| collection | DOAJ |
| description | Abstract Background Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata). Results We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA receptors suppressed metamorphosis triggered by attachment to a substrate. Gene expressions of the RA signaling component were detected in competent larvae. Conclusions This study provides insight into the ancestral function of RA signaling, which is conserved in the metamorphosis of cnidarians and starfish. |
| first_indexed | 2024-12-22T09:37:20Z |
| format | Article |
| id | doaj.art-00b50a1e54594a13b20e24ecd127c92c |
| institution | Directory Open Access Journal |
| issn | 2041-9139 |
| language | English |
| last_indexed | 2024-12-22T09:37:20Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | EvoDevo |
| spelling | doaj.art-00b50a1e54594a13b20e24ecd127c92c2022-12-21T18:30:48ZengBMCEvoDevo2041-91392018-04-019111110.1186/s13227-018-0098-xThe role of retinoic acid signaling in starfish metamorphosisShumpei Yamakawa0Yoshiaki Morino1Masanao Honda2Hiroshi Wada3Graduate School of Life and Environmental Sciences, University of TsukubaGraduate School of Life and Environmental Sciences, University of TsukubaGraduate School of Life and Environmental Sciences, University of TsukubaGraduate School of Life and Environmental Sciences, University of TsukubaAbstract Background Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata). Results We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA receptors suppressed metamorphosis triggered by attachment to a substrate. Gene expressions of the RA signaling component were detected in competent larvae. Conclusions This study provides insight into the ancestral function of RA signaling, which is conserved in the metamorphosis of cnidarians and starfish.http://link.springer.com/article/10.1186/s13227-018-0098-xRetinoic acid signalingMetamorphosisEchinodermStarfish |
| spellingShingle | Shumpei Yamakawa Yoshiaki Morino Masanao Honda Hiroshi Wada The role of retinoic acid signaling in starfish metamorphosis EvoDevo Retinoic acid signaling Metamorphosis Echinoderm Starfish |
| title | The role of retinoic acid signaling in starfish metamorphosis |
| title_full | The role of retinoic acid signaling in starfish metamorphosis |
| title_fullStr | The role of retinoic acid signaling in starfish metamorphosis |
| title_full_unstemmed | The role of retinoic acid signaling in starfish metamorphosis |
| title_short | The role of retinoic acid signaling in starfish metamorphosis |
| title_sort | role of retinoic acid signaling in starfish metamorphosis |
| topic | Retinoic acid signaling Metamorphosis Echinoderm Starfish |
| url | http://link.springer.com/article/10.1186/s13227-018-0098-x |
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