Assessment of subclinical renal dysfunction in post COVID-19 patients
ABSTRACTIntroduction Kidney damage in COVID-19 is common and may lead to CKD. Early recognition of progression is mandatory, so there is a need for sensitive markers of kidney damage. Renal functional reserve (RFR) is described as the ability of the kidneys to augment their function in special situa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Alexandria Journal of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20905068.2024.2333595 |
| _version_ | 1797230430951309312 |
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| author | Peter AtefMikhael Salah Said Naga Sherif Aziz Zaki Amira Hussein Mohamed |
| author_facet | Peter AtefMikhael Salah Said Naga Sherif Aziz Zaki Amira Hussein Mohamed |
| author_sort | Peter AtefMikhael |
| collection | DOAJ |
| description | ABSTRACTIntroduction Kidney damage in COVID-19 is common and may lead to CKD. Early recognition of progression is mandatory, so there is a need for sensitive markers of kidney damage. Renal functional reserve (RFR) is described as the ability of the kidneys to augment their function in special situations.Aim of Work Was to assess subclinical renal dysfunction post-COVID-19.Methods This cross-sectional study investigates 31 patients previously infected with COVID-19 within 2–3 months and 31 healthy subjects with matched age and sex. Assessment of RFR was done by calculating the estimated GFR using the CKD-EPI equation before and 2 hours after 80 g protein load by intravenous infusion.Results RFR was significantly lower in post-COVID-19 patients (mean of 11.19 ± 4.76) than the control (mean of 25.81 ± 4.42, p < 0.001).Conclusion Despite preserved eGFR, there is a reduction in RFR, indicating progressive loss of nephron mass post-COVID. |
| first_indexed | 2024-04-24T15:28:22Z |
| format | Article |
| id | doaj.art-00b5f96567d84270862e01aa51e271eb |
| institution | Directory Open Access Journal |
| issn | 2090-5068 2090-5076 |
| language | English |
| last_indexed | 2024-04-24T15:28:22Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Alexandria Journal of Medicine |
| spelling | doaj.art-00b5f96567d84270862e01aa51e271eb2024-04-02T05:11:14ZengTaylor & Francis GroupAlexandria Journal of Medicine2090-50682090-50762024-12-01601768110.1080/20905068.2024.2333595Assessment of subclinical renal dysfunction in post COVID-19 patientsPeter AtefMikhael0Salah Said Naga1Sherif Aziz Zaki2Amira Hussein Mohamed3Internal Medicine Department, Medical Research Institute, Alexandria, EgyptInternal Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptInternal Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, EgyptInternal Medicine Department, Medical Research Institute, Alexandria University Medicine, Alexandria, EgyptABSTRACTIntroduction Kidney damage in COVID-19 is common and may lead to CKD. Early recognition of progression is mandatory, so there is a need for sensitive markers of kidney damage. Renal functional reserve (RFR) is described as the ability of the kidneys to augment their function in special situations.Aim of Work Was to assess subclinical renal dysfunction post-COVID-19.Methods This cross-sectional study investigates 31 patients previously infected with COVID-19 within 2–3 months and 31 healthy subjects with matched age and sex. Assessment of RFR was done by calculating the estimated GFR using the CKD-EPI equation before and 2 hours after 80 g protein load by intravenous infusion.Results RFR was significantly lower in post-COVID-19 patients (mean of 11.19 ± 4.76) than the control (mean of 25.81 ± 4.42, p < 0.001).Conclusion Despite preserved eGFR, there is a reduction in RFR, indicating progressive loss of nephron mass post-COVID.https://www.tandfonline.com/doi/10.1080/20905068.2024.2333595COVID-19renal functional reservechronic kidney disease |
| spellingShingle | Peter AtefMikhael Salah Said Naga Sherif Aziz Zaki Amira Hussein Mohamed Assessment of subclinical renal dysfunction in post COVID-19 patients Alexandria Journal of Medicine COVID-19 renal functional reserve chronic kidney disease |
| title | Assessment of subclinical renal dysfunction in post COVID-19 patients |
| title_full | Assessment of subclinical renal dysfunction in post COVID-19 patients |
| title_fullStr | Assessment of subclinical renal dysfunction in post COVID-19 patients |
| title_full_unstemmed | Assessment of subclinical renal dysfunction in post COVID-19 patients |
| title_short | Assessment of subclinical renal dysfunction in post COVID-19 patients |
| title_sort | assessment of subclinical renal dysfunction in post covid 19 patients |
| topic | COVID-19 renal functional reserve chronic kidney disease |
| url | https://www.tandfonline.com/doi/10.1080/20905068.2024.2333595 |
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