A Mini-Review on Detection Methods of Microcystins
Cyanobacterial harmful algal blooms (CyanoHABs) produce microcystins (MCs) which are associated with animal and human hepatotoxicity. Over 270 variants of MC exist. MCs have been continually studied due of their toxic consequences. Monitoring water quality to assess the presence of MCs is of utmost...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/10/641 |
| _version_ | 1797551740249178112 |
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| author | Isaac Yaw Massey Pian Wu Jia Wei Jiayou Luo Ping Ding Haiyan Wei Fei Yang |
| author_facet | Isaac Yaw Massey Pian Wu Jia Wei Jiayou Luo Ping Ding Haiyan Wei Fei Yang |
| author_sort | Isaac Yaw Massey |
| collection | DOAJ |
| description | Cyanobacterial harmful algal blooms (CyanoHABs) produce microcystins (MCs) which are associated with animal and human hepatotoxicity. Over 270 variants of MC exist. MCs have been continually studied due of their toxic consequences. Monitoring water quality to assess the presence of MCs is of utmost importance although it is often difficult because CyanoHABs may generate multiple MC variants, and their low concentration in water. To effectively manage and control these toxins and prevent their health risks, sensitive, fast, and reliable methods capable of detecting MCs are required. This paper aims to review the three main analytical methods used to detect MCs ranging from biological (mouse bioassay), biochemical (protein phosphatase inhibition assay and enzyme linked immunosorbent assay), and chemical (high performance liquid chromatography, liquid chromatography-mass spectrometry, high performance capillary electrophoresis, and gas chromatography), as well as the newly emerging biosensor methods. In addition, the current state of these methods regarding their novel development and usage, as well as merits and limitations are presented. Finally, this paper also provides recommendations and future research directions towards method application and improvement. |
| first_indexed | 2024-03-10T15:50:18Z |
| format | Article |
| id | doaj.art-00b6db5f71df4410a0c7b0afd8435eca |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T15:50:18Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-00b6db5f71df4410a0c7b0afd8435eca2023-11-20T16:02:59ZengMDPI AGToxins2072-66512020-10-01121064110.3390/toxins12100641A Mini-Review on Detection Methods of MicrocystinsIsaac Yaw Massey0Pian Wu1Jia Wei2Jiayou Luo3Ping Ding4Haiyan Wei5Fei Yang6Xiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaDepartment of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, ChinaXiangya School of Public Health, Central South University, Changsha 410078, ChinaCyanobacterial harmful algal blooms (CyanoHABs) produce microcystins (MCs) which are associated with animal and human hepatotoxicity. Over 270 variants of MC exist. MCs have been continually studied due of their toxic consequences. Monitoring water quality to assess the presence of MCs is of utmost importance although it is often difficult because CyanoHABs may generate multiple MC variants, and their low concentration in water. To effectively manage and control these toxins and prevent their health risks, sensitive, fast, and reliable methods capable of detecting MCs are required. This paper aims to review the three main analytical methods used to detect MCs ranging from biological (mouse bioassay), biochemical (protein phosphatase inhibition assay and enzyme linked immunosorbent assay), and chemical (high performance liquid chromatography, liquid chromatography-mass spectrometry, high performance capillary electrophoresis, and gas chromatography), as well as the newly emerging biosensor methods. In addition, the current state of these methods regarding their novel development and usage, as well as merits and limitations are presented. Finally, this paper also provides recommendations and future research directions towards method application and improvement.https://www.mdpi.com/2072-6651/12/10/641detectionmicrocystinsELISAHPLC-MSbiosensor |
| spellingShingle | Isaac Yaw Massey Pian Wu Jia Wei Jiayou Luo Ping Ding Haiyan Wei Fei Yang A Mini-Review on Detection Methods of Microcystins Toxins detection microcystins ELISA HPLC-MS biosensor |
| title | A Mini-Review on Detection Methods of Microcystins |
| title_full | A Mini-Review on Detection Methods of Microcystins |
| title_fullStr | A Mini-Review on Detection Methods of Microcystins |
| title_full_unstemmed | A Mini-Review on Detection Methods of Microcystins |
| title_short | A Mini-Review on Detection Methods of Microcystins |
| title_sort | mini review on detection methods of microcystins |
| topic | detection microcystins ELISA HPLC-MS biosensor |
| url | https://www.mdpi.com/2072-6651/12/10/641 |
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