Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens
Abstract Accurate determination of resection margins in breast specimens is important as complete removal of malignancy is a prerequisite for patients’ outcome. Mammography (DM) as 2D-technique provides only limited value in margin assessment. Therefore, we investigated whether cone-beam computed to...
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| Format: | Article |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21616-3 |
| _version_ | 1811249902408171520 |
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| author | Claudia Neubauer Jannina Samantha Yilmaz Peter Bronsert Martin Pichotka Fabian Bamberg Marisa Windfuhr-Blum Thalia Erbes Jakob Neubauer |
| author_facet | Claudia Neubauer Jannina Samantha Yilmaz Peter Bronsert Martin Pichotka Fabian Bamberg Marisa Windfuhr-Blum Thalia Erbes Jakob Neubauer |
| author_sort | Claudia Neubauer |
| collection | DOAJ |
| description | Abstract Accurate determination of resection margins in breast specimens is important as complete removal of malignancy is a prerequisite for patients’ outcome. Mammography (DM) as 2D-technique provides only limited value in margin assessment. Therefore, we investigated whether cone-beam computed tomography (CBCT) or digital breast tomosynthesis (DBT) has incremental value in assessing margins to microcalcifications. Three independent readers investigated breast specimens for presence of microcalcifications and the smallest distance to margins. Histopathology served as gold standard. Microcalcifications were detected in 15 out of 21 included specimens (71%). Pooled sensitivity for DM, DBT and CBCT for microcalcifications compared to preoperative DM was 0.98 (CI 0.94–0.99), 0.83 (CI 0.73–0.94) and 0.94 (CI 0.87–0.99), pooled specificity was 0.99 (CI 0.99–0.99), 0.73 (CI 0.51–0.96) and 0.60 (CI 0.35–0.85). Mean measurement error for margin determination for DM, DBT and CBCT was 10 mm, 14 mm and 6 mm (p = 0.002) with significant difference between CBCT and the other devices (p < 0.03). Mean reading time required by the readers to analyze DM, DBT and CBCT, was 36, 43 and 54 s (p < 0.001). Although DM allows reliable detection of microcalcifications, measurement of resection margin was significantly more accurate with CBCT. Thus, a combination of methods or improved CBCT might provide a more accurate determination of disease-free margins in breast specimens. |
| first_indexed | 2024-04-12T15:54:36Z |
| format | Article |
| id | doaj.art-00b82a4a2b1d44de9343db4804121d28 |
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| language | English |
| last_indexed | 2024-04-12T15:54:36Z |
| publishDate | 2022-10-01 |
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| series | Scientific Reports |
| spelling | doaj.art-00b82a4a2b1d44de9343db4804121d282022-12-22T03:26:23ZengNature PortfolioScientific Reports2045-23222022-10-011211910.1038/s41598-022-21616-3Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimensClaudia Neubauer0Jannina Samantha Yilmaz1Peter Bronsert2Martin Pichotka3Fabian Bamberg4Marisa Windfuhr-Blum5Thalia Erbes6Jakob Neubauer7Department of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgInstitute for Surgical Pathology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgMedical Physics, Department of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Obstetrics and Gynecology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgDepartment of Radiology, Medical Center, University of Freiburg, Faculty of Medicine, University of FreiburgAbstract Accurate determination of resection margins in breast specimens is important as complete removal of malignancy is a prerequisite for patients’ outcome. Mammography (DM) as 2D-technique provides only limited value in margin assessment. Therefore, we investigated whether cone-beam computed tomography (CBCT) or digital breast tomosynthesis (DBT) has incremental value in assessing margins to microcalcifications. Three independent readers investigated breast specimens for presence of microcalcifications and the smallest distance to margins. Histopathology served as gold standard. Microcalcifications were detected in 15 out of 21 included specimens (71%). Pooled sensitivity for DM, DBT and CBCT for microcalcifications compared to preoperative DM was 0.98 (CI 0.94–0.99), 0.83 (CI 0.73–0.94) and 0.94 (CI 0.87–0.99), pooled specificity was 0.99 (CI 0.99–0.99), 0.73 (CI 0.51–0.96) and 0.60 (CI 0.35–0.85). Mean measurement error for margin determination for DM, DBT and CBCT was 10 mm, 14 mm and 6 mm (p = 0.002) with significant difference between CBCT and the other devices (p < 0.03). Mean reading time required by the readers to analyze DM, DBT and CBCT, was 36, 43 and 54 s (p < 0.001). Although DM allows reliable detection of microcalcifications, measurement of resection margin was significantly more accurate with CBCT. Thus, a combination of methods or improved CBCT might provide a more accurate determination of disease-free margins in breast specimens.https://doi.org/10.1038/s41598-022-21616-3 |
| spellingShingle | Claudia Neubauer Jannina Samantha Yilmaz Peter Bronsert Martin Pichotka Fabian Bamberg Marisa Windfuhr-Blum Thalia Erbes Jakob Neubauer Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens Scientific Reports |
| title | Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens |
| title_full | Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens |
| title_fullStr | Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens |
| title_full_unstemmed | Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens |
| title_short | Accuracy of cone-beam computed tomography, digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens |
| title_sort | accuracy of cone beam computed tomography digital mammography and digital breast tomosynthesis for microcalcifications and margins to microcalcifications in breast specimens |
| url | https://doi.org/10.1038/s41598-022-21616-3 |
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