Radiation Biomarkers in Large Scale Human Health Effects Studies
Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/10/4/155 |
| _version_ | 1797551810729213952 |
|---|---|
| author | Jayne Moquet Kai Rothkamm Stephen Barnard Elizabeth Ainsbury |
| author_facet | Jayne Moquet Kai Rothkamm Stephen Barnard Elizabeth Ainsbury |
| author_sort | Jayne Moquet |
| collection | DOAJ |
| description | Following recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward. |
| first_indexed | 2024-03-10T15:51:22Z |
| format | Article |
| id | doaj.art-00b8976d3d87401cb9783726ec5ecb27 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T15:51:22Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-00b8976d3d87401cb9783726ec5ecb272023-11-20T16:01:27ZengMDPI AGJournal of Personalized Medicine2075-44262020-10-0110415510.3390/jpm10040155Radiation Biomarkers in Large Scale Human Health Effects StudiesJayne Moquet0Kai Rothkamm1Stephen Barnard2Elizabeth Ainsbury3Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UKPublic Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UKPublic Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UKPublic Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UKFollowing recent developments, the RENEB network (Running the European Network of biological dosimetry and physical retrospective dosimetry) is in an excellent position to carry out large scale molecular epidemiological studies of ionizing radiation effects, with validated expertise in the dicentric, fluorescent in situ hybridization (FISH)-translocation, micronucleus, premature chromosome condensation, gamma-H2AX foci and gene expression assays. Large scale human health effects studies present complex challenges such as the practical aspects of sample logistics, assay costs, effort, effect modifiers and quality control/assurance measures. At Public Health England, the dicentric, automated micronucleus and gamma-H2AX radiation-induced foci assays have been tested for use in a large health effects study. The results of the study and the experience gained in carrying out such a large scale investigation provide valuable information that could help minimise random and systematic errors in biomarker data sets for health surveillance analyses going forward.https://www.mdpi.com/2075-4426/10/4/155ionizing radiationbiomarkersdicentric assaymicronucleus assaygamma H2AX foci assayhealth surveillance analyses |
| spellingShingle | Jayne Moquet Kai Rothkamm Stephen Barnard Elizabeth Ainsbury Radiation Biomarkers in Large Scale Human Health Effects Studies Journal of Personalized Medicine ionizing radiation biomarkers dicentric assay micronucleus assay gamma H2AX foci assay health surveillance analyses |
| title | Radiation Biomarkers in Large Scale Human Health Effects Studies |
| title_full | Radiation Biomarkers in Large Scale Human Health Effects Studies |
| title_fullStr | Radiation Biomarkers in Large Scale Human Health Effects Studies |
| title_full_unstemmed | Radiation Biomarkers in Large Scale Human Health Effects Studies |
| title_short | Radiation Biomarkers in Large Scale Human Health Effects Studies |
| title_sort | radiation biomarkers in large scale human health effects studies |
| topic | ionizing radiation biomarkers dicentric assay micronucleus assay gamma H2AX foci assay health surveillance analyses |
| url | https://www.mdpi.com/2075-4426/10/4/155 |
| work_keys_str_mv | AT jaynemoquet radiationbiomarkersinlargescalehumanhealtheffectsstudies AT kairothkamm radiationbiomarkersinlargescalehumanhealtheffectsstudies AT stephenbarnard radiationbiomarkersinlargescalehumanhealtheffectsstudies AT elizabethainsbury radiationbiomarkersinlargescalehumanhealtheffectsstudies |