High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography
Abstract Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast ag...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01363-3 |
| _version_ | 1817992262332710912 |
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| author | Zhuang Liu Menglong Zhao Han Wang Zi Fu Hongbo Gao Weijun Peng Dalong Ni Wei Tang Yajia Gu |
| author_facet | Zhuang Liu Menglong Zhao Han Wang Zi Fu Hongbo Gao Weijun Peng Dalong Ni Wei Tang Yajia Gu |
| author_sort | Zhuang Liu |
| collection | DOAJ |
| description | Abstract Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T 1 -weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for Gd3+ coordination to improve the relaxivity and avoid leakage of the Gd3+ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 mM− 1 s− 1 at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T 1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstract |
| first_indexed | 2024-04-14T01:24:04Z |
| format | Article |
| id | doaj.art-00b8cdd4f69c4ba5888459fcc0aa4e5f |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T01:24:04Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-00b8cdd4f69c4ba5888459fcc0aa4e5f2022-12-22T02:20:31ZengBMCJournal of Nanobiotechnology1477-31552022-03-0120111110.1186/s12951-022-01363-3High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiographyZhuang Liu0Menglong Zhao1Han Wang2Zi Fu3Hongbo Gao4Weijun Peng5Dalong Ni6Wei Tang7Yajia Gu8Department of Radiology, Fudan University Shanghai Cancer CenterDepartment of Radiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Medical ImagingDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Radiology, Fudan University Shanghai Cancer CenterDepartment of Radiation Oncology, Huadong Hospital Affiliated to Fudan UniversityDepartment of Radiology, Fudan University Shanghai Cancer CenterDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Radiology, Fudan University Shanghai Cancer CenterDepartment of Radiology, Fudan University Shanghai Cancer CenterAbstract Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal ion-released potential long-term toxicity of clinical available Gd-based contrast agents. In this work, we report a facile and efficient strategy to achieve Gd-chelated organic nanoparticles with high relaxivity for T 1 -weighted MRA imaging. The Gd-chelated PEG-TCPP nanoparticles (GPT NPs) have been engineered composite structured consisting of Gd-chelated TCPP and PEG. The spherical structure of TCPP offers more chemical sites for Gd3+ coordination to improve the relaxivity and avoid leakage of the Gd3+ ions. The synthesized GPT NPs exhibit a high relaxation rate of 35.76 mM− 1 s− 1 at 3.0 T, which is higher than the rates for most reported MR contrast agents. Therefore, GPT NPs can be used for MRA with much stronger vascular signals, longer circulation time, and high-resolution arterial vascular visualization than those using clinical MR contrast agents at the same dose. This work may make the T 1 MRI contrast agents for high-resolution angiography possible and offer a new candidate for preclinical and clinical applications of MR vascular imaging and vascular disease diagnosis. Graphical Abstracthttps://doi.org/10.1186/s12951-022-01363-3MR angiographyContrast agentVascular imagingMagnetic nanoparticlesGd-chelate |
| spellingShingle | Zhuang Liu Menglong Zhao Han Wang Zi Fu Hongbo Gao Weijun Peng Dalong Ni Wei Tang Yajia Gu High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography Journal of Nanobiotechnology MR angiography Contrast agent Vascular imaging Magnetic nanoparticles Gd-chelate |
| title | High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography |
| title_full | High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography |
| title_fullStr | High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography |
| title_full_unstemmed | High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography |
| title_short | High relaxivity Gd3+-based organic nanoparticles for efficient magnetic resonance angiography |
| title_sort | high relaxivity gd3 based organic nanoparticles for efficient magnetic resonance angiography |
| topic | MR angiography Contrast agent Vascular imaging Magnetic nanoparticles Gd-chelate |
| url | https://doi.org/10.1186/s12951-022-01363-3 |
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