IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice

IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice

AimsCytokine storm is closely related to the initiation and progression of sepsis, and the level of IL-6 is positively correlated with mortality and organ dysfunction. Sepsis-induced myocardial dysfunction (SIMD) is one of the major complications. However, the role of the IL-6/STAT3 signaling in the...

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Bibliographic Details
Main Authors: Tao Jiang, Dewei Peng, Wei Shi, Junyi Guo, Shengqi Huo, Lintong Men, Cuntai Zhang, Sheng Li, Jiagao Lv, Li Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
sepsis-induced myocardial dysfunction
FUNDC1
MAMs
mitophagy
calcium signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.790612/full

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