Oncogenic p53 triggers amyloid aggregation of p63 and p73 liquid droplets

Oncogenic p53 triggers amyloid aggregation of p63 and p73 liquid droplets

Abstract P53 Phase separation is crucial towards amyloid aggregation and p63 and p73 have enhanced expression in tumors. This study examines the phase behaviors of p53, p63, and p73. Here we show that unlike the DNA-binding domain of p53 (p53C), the p63C and p73C undergo phase separation, but do not...

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Bibliographic Details
Main Authors: Elaine C. Petronilho, Guilherme C. de Andrade, Gileno dos S. de Sousa, Fernando P. Almeida, Michelle F. Mota, Ana Vitória dos S. Gomes, Carlos Henrique S. Pinheiro, Mylena C. da Silva, Hiam R. S. Arruda, Mayra A. Marques, Tuane C. R. G. Vieira, Guilherme A. P. de Oliveira, Jerson L. Silva
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-024-01289-x

Internet

https://doi.org/10.1038/s42004-024-01289-x

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