Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment
Zhonghua Zou,1 Jinping Li,2 Xiang Ji,2 Tingxing Wang,1 Qingqing Chen,1 Zhengcao Liu,1 Shengjun Ji1 1Department of Radiotherapy & Oncology, the Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, People’s Republic of China; 2Department of Gas...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-02-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/naples-prognostic-score-as-an-independent-predictor-of-survival-outcom-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797894436603035648 |
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| author | Zou Z Li J Ji X Wang T Chen Q Liu Z Ji S |
| author_facet | Zou Z Li J Ji X Wang T Chen Q Liu Z Ji S |
| author_sort | Zou Z |
| collection | DOAJ |
| description | Zhonghua Zou,1 Jinping Li,2 Xiang Ji,2 Tingxing Wang,1 Qingqing Chen,1 Zhengcao Liu,1 Shengjun Ji1 1Department of Radiotherapy & Oncology, the Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, People’s Republic of China; 2Department of Gastroenterology, Fangzi People’s Hospital, Weifang, People’s Republic of ChinaCorrespondence: Shengjun Ji, Department of Radiotherapy & Oncology, the affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, No. 16 Baita Road, Suzhou, 215001, People’s Republic of China, Email drshengjunji@163.comBackground: The Naples Prognostic Score (NPS) can reflect patient’s nutritional and inflammatory status, which is identified as a prognostic indicator for various malignant tumors. However, its significance in patients with resected locally advanced non-small cell lung cancer (LA-NSCLC) patients who receive neoadjuvant treatment remains unclear so far.Methods: A total of 165 LA-NSCLC patients surgically treated from May 2012 to November 2017 were retrospectively investigated. The LA-NSCLC patients were divided into three groups according to NPS scores. The receiver operating curve (ROC) analysis was performed to reveal the discriminatory ability of NPS and other indicators for predicting the survival. The NPS and clinicopathological variables were further evaluated the prognostic value by univariate and multivariate Cox analysis.Results: The NPS was related to age (P = 0.046), smoking history (P = 0.004), Eastern Cooperative Oncology Group (ECOG) score (P = 0.005), and adjuvant treatment (P = 0.017). Patients with high NPS scores had worse overall survival (OS) (group 1 vs 0, P = 0.006; group 2 vs 0, P < 0.001) and disease-free survival (DFS) (group 1 vs 0, P < 0.001; group 2 vs 0, P < 0.001). The ROC analysis demonstrated that NPS had better predictive ability than other prognostic indicators. Multivariate analysis revealed that NPS was independent prognostic indicator of OS (group 1 vs 0, hazard ratio [HR] =2.591, P = 0.023; group 2 vs 0, HR = 8.744, P = 0.001) and DFS (group 1 vs 0, HR =3.754, P < 0.001; group 2 vs 0, HR = 9.673, P < 0.001).Conclusion: The NPS could be an independent prognostic indicator in patients with resected LA-NSCLC receiving neoadjuvant treatment and more reliable than the other nutritional and inflammatory indicators.Keywords: surgery, locally advanced NSCLC, NPS, prognosis, neoadjuvant treatment |
| first_indexed | 2024-04-10T07:10:08Z |
| format | Article |
| id | doaj.art-00ba56925b994a039384b7bad2ef56ee |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-10T07:10:08Z |
| publishDate | 2023-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-00ba56925b994a039384b7bad2ef56ee2023-02-26T15:41:34ZengDove Medical PressJournal of Inflammation Research1178-70312023-02-01Volume 1679380781849Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant TreatmentZou ZLi JJi XWang TChen QLiu ZJi SZhonghua Zou,1 Jinping Li,2 Xiang Ji,2 Tingxing Wang,1 Qingqing Chen,1 Zhengcao Liu,1 Shengjun Ji1 1Department of Radiotherapy & Oncology, the Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, Suzhou, People’s Republic of China; 2Department of Gastroenterology, Fangzi People’s Hospital, Weifang, People’s Republic of ChinaCorrespondence: Shengjun Ji, Department of Radiotherapy & Oncology, the affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, No. 16 Baita Road, Suzhou, 215001, People’s Republic of China, Email drshengjunji@163.comBackground: The Naples Prognostic Score (NPS) can reflect patient’s nutritional and inflammatory status, which is identified as a prognostic indicator for various malignant tumors. However, its significance in patients with resected locally advanced non-small cell lung cancer (LA-NSCLC) patients who receive neoadjuvant treatment remains unclear so far.Methods: A total of 165 LA-NSCLC patients surgically treated from May 2012 to November 2017 were retrospectively investigated. The LA-NSCLC patients were divided into three groups according to NPS scores. The receiver operating curve (ROC) analysis was performed to reveal the discriminatory ability of NPS and other indicators for predicting the survival. The NPS and clinicopathological variables were further evaluated the prognostic value by univariate and multivariate Cox analysis.Results: The NPS was related to age (P = 0.046), smoking history (P = 0.004), Eastern Cooperative Oncology Group (ECOG) score (P = 0.005), and adjuvant treatment (P = 0.017). Patients with high NPS scores had worse overall survival (OS) (group 1 vs 0, P = 0.006; group 2 vs 0, P < 0.001) and disease-free survival (DFS) (group 1 vs 0, P < 0.001; group 2 vs 0, P < 0.001). The ROC analysis demonstrated that NPS had better predictive ability than other prognostic indicators. Multivariate analysis revealed that NPS was independent prognostic indicator of OS (group 1 vs 0, hazard ratio [HR] =2.591, P = 0.023; group 2 vs 0, HR = 8.744, P = 0.001) and DFS (group 1 vs 0, HR =3.754, P < 0.001; group 2 vs 0, HR = 9.673, P < 0.001).Conclusion: The NPS could be an independent prognostic indicator in patients with resected LA-NSCLC receiving neoadjuvant treatment and more reliable than the other nutritional and inflammatory indicators.Keywords: surgery, locally advanced NSCLC, NPS, prognosis, neoadjuvant treatmenthttps://www.dovepress.com/naples-prognostic-score-as-an-independent-predictor-of-survival-outcom-peer-reviewed-fulltext-article-JIRsurgerylocally advanced nsclcnpsprognosisneoadjuvant treatment |
| spellingShingle | Zou Z Li J Ji X Wang T Chen Q Liu Z Ji S Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment Journal of Inflammation Research surgery locally advanced nsclc nps prognosis neoadjuvant treatment |
| title | Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment |
| title_full | Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment |
| title_fullStr | Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment |
| title_full_unstemmed | Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment |
| title_short | Naples Prognostic Score as an Independent Predictor of Survival Outcomes for Resected Locally Advanced Non-Small Cell Lung Cancer Patients After Neoadjuvant Treatment |
| title_sort | naples prognostic score as an independent predictor of survival outcomes for resected locally advanced non small cell lung cancer patients after neoadjuvant treatment |
| topic | surgery locally advanced nsclc nps prognosis neoadjuvant treatment |
| url | https://www.dovepress.com/naples-prognostic-score-as-an-independent-predictor-of-survival-outcom-peer-reviewed-fulltext-article-JIR |
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