Forming and waking dormant cells: The ppGpp ribosome dimerization persister model
Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence. No mutations occur, and so persisters behave like wild-type cells upon removal of the stress and regrowth; hence,...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | Biofilm |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590207519300188 |
| _version_ | 1818647817096265728 |
|---|---|
| author | Thomas K. Wood Sooyeon Song |
| author_facet | Thomas K. Wood Sooyeon Song |
| author_sort | Thomas K. Wood |
| collection | DOAJ |
| description | Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence. No mutations occur, and so persisters behave like wild-type cells upon removal of the stress and regrowth; hence, persisters are phenotypic variants. In contrast, resistant bacteria have mutations that allow cells to grow in the presence of antibiotics, and tolerant cells survive antibiotics better than actively-growing cells due to their slow growth (such as that of the stationary phase). In this review, we focus on the latest developments in studies related to the formation and resuscitation of persister cells and propose the guanosine pentaphosphate/tetraphosphate (henceforth ppGpp) ribosome dimerization persister (PRDP) model for entering and exiting the persister state. |
| first_indexed | 2024-12-17T01:08:33Z |
| format | Article |
| id | doaj.art-00ba8f2b407944a796eb3a1aae6f66ae |
| institution | Directory Open Access Journal |
| issn | 2590-2075 |
| language | English |
| last_indexed | 2024-12-17T01:08:33Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biofilm |
| spelling | doaj.art-00ba8f2b407944a796eb3a1aae6f66ae2022-12-21T22:09:12ZengElsevierBiofilm2590-20752020-12-012100018Forming and waking dormant cells: The ppGpp ribosome dimerization persister modelThomas K. Wood0Sooyeon Song1Corresponding author.; Department of Chemical Engineering, Pennsylvania State University, University Park, PA, 16802-4400, USADepartment of Chemical Engineering, Pennsylvania State University, University Park, PA, 16802-4400, USAProcaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence. No mutations occur, and so persisters behave like wild-type cells upon removal of the stress and regrowth; hence, persisters are phenotypic variants. In contrast, resistant bacteria have mutations that allow cells to grow in the presence of antibiotics, and tolerant cells survive antibiotics better than actively-growing cells due to their slow growth (such as that of the stationary phase). In this review, we focus on the latest developments in studies related to the formation and resuscitation of persister cells and propose the guanosine pentaphosphate/tetraphosphate (henceforth ppGpp) ribosome dimerization persister (PRDP) model for entering and exiting the persister state.http://www.sciencedirect.com/science/article/pii/S2590207519300188PersistenceAntimicrobial agentsTolerance |
| spellingShingle | Thomas K. Wood Sooyeon Song Forming and waking dormant cells: The ppGpp ribosome dimerization persister model Biofilm Persistence Antimicrobial agents Tolerance |
| title | Forming and waking dormant cells: The ppGpp ribosome dimerization persister model |
| title_full | Forming and waking dormant cells: The ppGpp ribosome dimerization persister model |
| title_fullStr | Forming and waking dormant cells: The ppGpp ribosome dimerization persister model |
| title_full_unstemmed | Forming and waking dormant cells: The ppGpp ribosome dimerization persister model |
| title_short | Forming and waking dormant cells: The ppGpp ribosome dimerization persister model |
| title_sort | forming and waking dormant cells the ppgpp ribosome dimerization persister model |
| topic | Persistence Antimicrobial agents Tolerance |
| url | http://www.sciencedirect.com/science/article/pii/S2590207519300188 |
| work_keys_str_mv | AT thomaskwood formingandwakingdormantcellstheppgppribosomedimerizationpersistermodel AT sooyeonsong formingandwakingdormantcellstheppgppribosomedimerizationpersistermodel |