Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents
Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/6/721 |
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| author | Amaia Iriondo-DeHond Patricia Martorell Salvador Genovés Daniel Ramón Konstantinos Stamatakis Manuel Fresno Antonio Molina Maria Dolores del Castillo |
| author_facet | Amaia Iriondo-DeHond Patricia Martorell Salvador Genovés Daniel Ramón Konstantinos Stamatakis Manuel Fresno Antonio Molina Maria Dolores del Castillo |
| author_sort | Amaia Iriondo-DeHond |
| collection | DOAJ |
| description | Nowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material. |
| first_indexed | 2024-12-19T20:03:40Z |
| format | Article |
| id | doaj.art-00bb0a32481347f281f022eb831230d5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T20:03:40Z |
| publishDate | 2016-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-00bb0a32481347f281f022eb831230d52022-12-21T20:07:35ZengMDPI AGMolecules1420-30492016-06-0121672110.3390/molecules21060721molecules21060721Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative AgentsAmaia Iriondo-DeHond0Patricia Martorell1Salvador Genovés2Daniel Ramón3Konstantinos Stamatakis4Manuel Fresno5Antonio Molina6Maria Dolores del Castillo7Institute of Food Science Research (CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, SpainBiópolis SL, Parc Científic Universitat de Valencia, Catedrático Agustín Escardino 9, edificio 2, 46980 Valencia, SpainBiópolis SL, Parc Científic Universitat de Valencia, Catedrático Agustín Escardino 9, edificio 2, 46980 Valencia, SpainBiópolis SL, Parc Científic Universitat de Valencia, Catedrático Agustín Escardino 9, edificio 2, 46980 Valencia, SpainCentro de Biología Molecular Severo Ochoa (CBM-SO) (CSIC-UAM), Nicolás Cabrera, 1, 28049 Madrid, SpainCentro de Biología Molecular Severo Ochoa (CBM-SO) (CSIC-UAM), Nicolás Cabrera, 1, 28049 Madrid, SpainBeacon Biomedicine, Parque Científico de Madrid, Santiago Grisolia 2, D130/L145, 28760 Madrid, SpainInstitute of Food Science Research (CSIC-UAM), Nicolás Cabrera 9, 28049 Madrid, SpainNowadays, coffee beans are almost exclusively used for the preparation of the beverage. The sustainability of coffee production can be achieved introducing new applications for the valorization of coffee by-products. Coffee silverskin is the by-product generated during roasting, and because of its powerful antioxidant capacity, coffee silverskin aqueous extract (CSE) may be used for other applications, such as antiaging cosmetics and dermaceutics. This study aims to contribute to the coffee sector’s sustainability through the application of CSE to preserve skin health. Preclinical data regarding the antiaging properties of CSE employing human keratinocytes and Caenorhabditis elegans are collected during the present study. Accelerated aging was induced by tert-butyl hydroperoxide (t-BOOH) in HaCaT cells and by ultraviolet radiation C (UVC) in C. elegans. Results suggest that the tested concentrations of coffee extracts were not cytotoxic, and CSE 1 mg/mL gave resistance to skin cells when oxidative damage was induced by t-BOOH. On the other hand, nematodes treated with CSE (1 mg/mL) showed a significant increased longevity compared to those cultured on a standard diet. In conclusion, our results support the antiaging properties of the CSE and its great potential for improving skin health due to its antioxidant character associated with phenols among other bioactive compounds present in the botanical material.http://www.mdpi.com/1420-3049/21/6/721coffee silverskinoxidative stressUVC radiationchlorogenic acidskin healthaccelerated agingnutricosmeticdermaceutic |
| spellingShingle | Amaia Iriondo-DeHond Patricia Martorell Salvador Genovés Daniel Ramón Konstantinos Stamatakis Manuel Fresno Antonio Molina Maria Dolores del Castillo Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents Molecules coffee silverskin oxidative stress UVC radiation chlorogenic acid skin health accelerated aging nutricosmetic dermaceutic |
| title | Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents |
| title_full | Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents |
| title_fullStr | Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents |
| title_full_unstemmed | Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents |
| title_short | Coffee Silverskin Extract Protects against Accelerated Aging Caused by Oxidative Agents |
| title_sort | coffee silverskin extract protects against accelerated aging caused by oxidative agents |
| topic | coffee silverskin oxidative stress UVC radiation chlorogenic acid skin health accelerated aging nutricosmetic dermaceutic |
| url | http://www.mdpi.com/1420-3049/21/6/721 |
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