Pluripotent stem cells: A therapeutic source for age-related macular degeneration
Age-related macular degeneration (AMD) leads to progressive loss of central vision in the elderly. At a cellular level, there is aging of the retinal pigment epithelial (RPE) cells, and accumulation of lipofuscin that interferes with the proper functioning of RPE which eventually leads to apoptosis....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=3;spage=177;epage=183;aulast=Parameswaran |
| _version_ | 1818899693597360128 |
|---|---|
| author | Sowmya Parameswaran Subramanian Krishnakumar |
| author_facet | Sowmya Parameswaran Subramanian Krishnakumar |
| author_sort | Sowmya Parameswaran |
| collection | DOAJ |
| description | Age-related macular degeneration (AMD) leads to progressive loss of central vision in the elderly. At a cellular level, there is aging of the retinal pigment epithelial (RPE) cells, and accumulation of lipofuscin that interferes with the proper functioning of RPE which eventually leads to apoptosis. Treatment depends on the stage of the disease. Wet AMD which has neovascularization is managed by local therapies such as laser photocoagulation and photodynamic therapy and is managed with injections of antivascular endothelial growth factor-based therapy. Unlike the wet AMD, an effective therapy does not exist for dry AMD and geographic atrophy. Cell replacement therapy has shown promise. This review discusses the opportunities in the various types of cell-based therapy, their limitations, and what is possible for India. |
| first_indexed | 2024-12-19T19:52:01Z |
| format | Article |
| id | doaj.art-00bc5f523e6e4e8d8e6ec71235b515de |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-19T19:52:01Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-00bc5f523e6e4e8d8e6ec71235b515de2022-12-21T20:07:55ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892017-01-0165317718310.4103/ijo.IJO_1026_15Pluripotent stem cells: A therapeutic source for age-related macular degenerationSowmya ParameswaranSubramanian KrishnakumarAge-related macular degeneration (AMD) leads to progressive loss of central vision in the elderly. At a cellular level, there is aging of the retinal pigment epithelial (RPE) cells, and accumulation of lipofuscin that interferes with the proper functioning of RPE which eventually leads to apoptosis. Treatment depends on the stage of the disease. Wet AMD which has neovascularization is managed by local therapies such as laser photocoagulation and photodynamic therapy and is managed with injections of antivascular endothelial growth factor-based therapy. Unlike the wet AMD, an effective therapy does not exist for dry AMD and geographic atrophy. Cell replacement therapy has shown promise. This review discusses the opportunities in the various types of cell-based therapy, their limitations, and what is possible for India.http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=3;spage=177;epage=183;aulast=ParameswaranAge-related macular degenerationembryonic stem cellsretinal pigment epithelialstem cells |
| spellingShingle | Sowmya Parameswaran Subramanian Krishnakumar Pluripotent stem cells: A therapeutic source for age-related macular degeneration Indian Journal of Ophthalmology Age-related macular degeneration embryonic stem cells retinal pigment epithelial stem cells |
| title | Pluripotent stem cells: A therapeutic source for age-related macular degeneration |
| title_full | Pluripotent stem cells: A therapeutic source for age-related macular degeneration |
| title_fullStr | Pluripotent stem cells: A therapeutic source for age-related macular degeneration |
| title_full_unstemmed | Pluripotent stem cells: A therapeutic source for age-related macular degeneration |
| title_short | Pluripotent stem cells: A therapeutic source for age-related macular degeneration |
| title_sort | pluripotent stem cells a therapeutic source for age related macular degeneration |
| topic | Age-related macular degeneration embryonic stem cells retinal pigment epithelial stem cells |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=3;spage=177;epage=183;aulast=Parameswaran |
| work_keys_str_mv | AT sowmyaparameswaran pluripotentstemcellsatherapeuticsourceforagerelatedmaculardegeneration AT subramaniankrishnakumar pluripotentstemcellsatherapeuticsourceforagerelatedmaculardegeneration |