Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses
Summary: Mycobacterium tuberculosis (Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH. We show that HIV antibodies are broader and more potent in PWH in the presence as compared to the absence of Mtb...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223007083 |
| _version_ | 1797837747551993856 |
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| author | Bukola Adeoye Lydia Nakiyingi Yvetane Moreau Ethel Nankya Alex J. Olson Mo Zhang Karen R. Jacobson Amita Gupta Yukari C. Manabe Mina C. Hosseinipour Johnstone Kumwenda Manish Sagar |
| author_facet | Bukola Adeoye Lydia Nakiyingi Yvetane Moreau Ethel Nankya Alex J. Olson Mo Zhang Karen R. Jacobson Amita Gupta Yukari C. Manabe Mina C. Hosseinipour Johnstone Kumwenda Manish Sagar |
| author_sort | Bukola Adeoye |
| collection | DOAJ |
| description | Summary: Mycobacterium tuberculosis (Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH. We show that HIV antibodies are broader and more potent in PWH in the presence as compared to the absence of Mtb disease. With co-existing Mtb disease, the virus in PWH also encounters unique antibody selection pressure. The Mtb-linked HIV antibody enhancement associates with specific mediators important for B cell and antibody development. This Mtb humoral augmentation does not occur due to cross-reactivity, a generalized increase in all antibodies, or differences in duration or amount of antigen exposure. We speculate that the co-localization of Mtb and HIV in lymphatic tissues leads to the emergence of potent HIV antibodies. PWH’s Mtb disease status has implications for the future use of HIV broadly neutralizing antibodies as prophylaxis or treatment and the induction of better humoral immunity. |
| first_indexed | 2024-04-09T15:29:40Z |
| format | Article |
| id | doaj.art-00bcdefcca2c461996a5598336e94a52 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T15:29:40Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-00bcdefcca2c461996a5598336e94a522023-04-28T08:56:11ZengElsevieriScience2589-00422023-05-01265106631Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responsesBukola Adeoye0Lydia Nakiyingi1Yvetane Moreau2Ethel Nankya3Alex J. Olson4Mo Zhang5Karen R. Jacobson6Amita Gupta7Yukari C. Manabe8Mina C. Hosseinipour9Johnstone Kumwenda10Manish Sagar11Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USAInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, UgandaDepartment of Medicine, Boston Medical Center, Boston, MA 02118, USADivision of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USADepartment of Medicine, Boston Medical Center, Boston, MA 02118, USADepartment of Medicine, Boston Medical Center, Boston, MA 02118, USADepartment of Medicine, Boston Medical Center, Boston, MA 02118, USADepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAUniversity of North Carolina School of Medicine, Chapel Hill, NC, USAUniversity of Malawi College of Medicine, Blantyre, MalawiDepartment of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA; Department of Medicine, Boston Medical Center, Boston, MA 02118, USA; Corresponding authorSummary: Mycobacterium tuberculosis (Mtb) is the most common infection among people with HIV (PWH). Mtb disease-associated inflammation could affect HIV-directed immune responses in PWH. We show that HIV antibodies are broader and more potent in PWH in the presence as compared to the absence of Mtb disease. With co-existing Mtb disease, the virus in PWH also encounters unique antibody selection pressure. The Mtb-linked HIV antibody enhancement associates with specific mediators important for B cell and antibody development. This Mtb humoral augmentation does not occur due to cross-reactivity, a generalized increase in all antibodies, or differences in duration or amount of antigen exposure. We speculate that the co-localization of Mtb and HIV in lymphatic tissues leads to the emergence of potent HIV antibodies. PWH’s Mtb disease status has implications for the future use of HIV broadly neutralizing antibodies as prophylaxis or treatment and the induction of better humoral immunity.http://www.sciencedirect.com/science/article/pii/S2589004223007083ImmunologyImmune responseMicrobiology |
| spellingShingle | Bukola Adeoye Lydia Nakiyingi Yvetane Moreau Ethel Nankya Alex J. Olson Mo Zhang Karen R. Jacobson Amita Gupta Yukari C. Manabe Mina C. Hosseinipour Johnstone Kumwenda Manish Sagar Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses iScience Immunology Immune response Microbiology |
| title | Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses |
| title_full | Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses |
| title_fullStr | Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses |
| title_full_unstemmed | Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses |
| title_short | Mycobacterium tuberculosis disease associates with higher HIV-1-specific antibody responses |
| title_sort | mycobacterium tuberculosis disease associates with higher hiv 1 specific antibody responses |
| topic | Immunology Immune response Microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223007083 |
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