Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level
Objective. To study the possibility of the 2D Speckle Tracking Imaging in early detection of cardiotoxicity in patients with triple negative breast cancer and arterial hypertension (AH) during anthracycline-containing chemotherapy. Materials and methods. 70 women (mean age 48.6±13.3 years) with trip...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IP Morozov P.V.
2017-12-01
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| Series: | Системные гипертензии |
| Subjects: | |
| Online Access: | https://syst-hypertension.ru/2075-082X/article/viewFile/29581/pdf |
| _version_ | 1818146869212086272 |
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| author | A A Avalyan M Yu Kirillova V N Shitov Ye V Oshchepkova M A Saidova M B Stenina I Ye Chazova |
| author_facet | A A Avalyan M Yu Kirillova V N Shitov Ye V Oshchepkova M A Saidova M B Stenina I Ye Chazova |
| author_sort | A A Avalyan |
| collection | DOAJ |
| description | Objective. To study the possibility of the 2D Speckle Tracking Imaging in early detection of cardiotoxicity in patients with triple negative breast cancer and arterial hypertension (AH) during anthracycline-containing chemotherapy. Materials and methods. 70 women (mean age 48.6±13.3 years) with triple negative breast cancer were enrolled. All patients underwent chemotherapy, including anthracycline, taxan, platinum-based agent. Echocardiography, including 2D Speckle Tracking Imaging, was performed on Vivid-E 9 ultrasound machine before and after 8 weeks of chemotherapy. Left ventricular ejection fraction (LVEF) (the biplane Simpson`s method) and global longitudinal strain (GLS) (mean normal GLS of -22.1±1.8 for women) were analysed. Patients were divided into two groups: group 1 - with AH (n=18) and group 2 - with normal blood pressure (n=52). Results. Before chemotherapy in group 1 GLS was lower than normal value (-19.1±2.8% vs -22.1±1.8%; p0.05). After chemotherapy in all patients GLS decrease was observed from -20.0±2.8% to -18.5±2.9% (p |
| first_indexed | 2024-12-11T12:26:12Z |
| format | Article |
| id | doaj.art-00bd6b114a904b0ebb1c56da122870bb |
| institution | Directory Open Access Journal |
| issn | 2075-082X 2542-2189 |
| language | Russian |
| last_indexed | 2024-12-11T12:26:12Z |
| publishDate | 2017-12-01 |
| publisher | IP Morozov P.V. |
| record_format | Article |
| series | Системные гипертензии |
| spelling | doaj.art-00bd6b114a904b0ebb1c56da122870bb2022-12-22T01:07:23ZrusIP Morozov P.V.Системные гипертензии2075-082X2542-21892017-12-01143212710.26442/2075-082X_14.3.21-2726609Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure levelA A Avalyan0M Yu Kirillova1V N Shitov2Ye V Oshchepkova3M A Saidova4M B Stenina5I Ye Chazova6A.L.Myasnikov Institute of Clinical Cardiology National Research Medical Center of Cardiology of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology National Research Medical Center of Cardiology of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology National Research Medical Center of Cardiology of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology National Research Medical Center of Cardiology of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology National Research Medical Center of Cardiology of the Ministry of Health of the Russian FederationN.N.Blokhin National Research Medical Center of Oncology of the Ministry of Health of the Russian FederationA.L.Myasnikov Institute of Clinical Cardiology National Research Medical Center of Cardiology of the Ministry of Health of the Russian FederationObjective. To study the possibility of the 2D Speckle Tracking Imaging in early detection of cardiotoxicity in patients with triple negative breast cancer and arterial hypertension (AH) during anthracycline-containing chemotherapy. Materials and methods. 70 women (mean age 48.6±13.3 years) with triple negative breast cancer were enrolled. All patients underwent chemotherapy, including anthracycline, taxan, platinum-based agent. Echocardiography, including 2D Speckle Tracking Imaging, was performed on Vivid-E 9 ultrasound machine before and after 8 weeks of chemotherapy. Left ventricular ejection fraction (LVEF) (the biplane Simpson`s method) and global longitudinal strain (GLS) (mean normal GLS of -22.1±1.8 for women) were analysed. Patients were divided into two groups: group 1 - with AH (n=18) and group 2 - with normal blood pressure (n=52). Results. Before chemotherapy in group 1 GLS was lower than normal value (-19.1±2.8% vs -22.1±1.8%; p0.05). After chemotherapy in all patients GLS decrease was observed from -20.0±2.8% to -18.5±2.9% (phttps://syst-hypertension.ru/2075-082X/article/viewFile/29581/pdfcardio-oncologyarterial hypertensioncardiotoxicityglobal longitudinal strain of the left ventriclechemotherapybreast cancer |
| spellingShingle | A A Avalyan M Yu Kirillova V N Shitov Ye V Oshchepkova M A Saidova M B Stenina I Ye Chazova Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level Системные гипертензии cardio-oncology arterial hypertension cardiotoxicity global longitudinal strain of the left ventricle chemotherapy breast cancer |
| title | Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level |
| title_full | Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level |
| title_fullStr | Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level |
| title_full_unstemmed | Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level |
| title_short | Markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level |
| title_sort | markers of early cardiotoxicity in patients with breast cancer undergoing chemotherapy depending on blood pressure level |
| topic | cardio-oncology arterial hypertension cardiotoxicity global longitudinal strain of the left ventricle chemotherapy breast cancer |
| url | https://syst-hypertension.ru/2075-082X/article/viewFile/29581/pdf |
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