Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data
Abstract Background In axial spondyloarthritis (axSpA), peripheral SpA (pSpA) and psoriatic arthritis (PsA), enthesitis is a hallmark clinical feature that can be assessed by the SPARCC index, LEI, MASES and MEI. These indices evaluate different locations, which may identify different numbers of pat...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Arthritis Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13075-023-03080-0 |
| _version_ | 1797806550635511808 |
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| author | Raquel Ena María Granados M. Lourdes Ladehesa-Pineda M. Ángeles Puche-Larrubia Alejandro Escudero-Contreras Maxime Dougados Eduardo Collantes-Estevez Clementina López-Medina |
| author_facet | Raquel Ena María Granados M. Lourdes Ladehesa-Pineda M. Ángeles Puche-Larrubia Alejandro Escudero-Contreras Maxime Dougados Eduardo Collantes-Estevez Clementina López-Medina |
| author_sort | Raquel Ena María Granados |
| collection | DOAJ |
| description | Abstract Background In axial spondyloarthritis (axSpA), peripheral SpA (pSpA) and psoriatic arthritis (PsA), enthesitis is a hallmark clinical feature that can be assessed by the SPARCC index, LEI, MASES and MEI. These indices evaluate different locations, which may identify different numbers of patients with enthesitis among SpA subtypes. Thus, the aim of this study was to evaluate whether the proportion of patients with at least one enthesitis across these three most prevalent SpA subtypes differs according to the index used and to evaluate the level of agreement among indices in detecting patients with enthesitis. Methods A total of 4185 patients (2719 axSpA, 433 pSpA and 1033 PsA) from the international and cross-sectional ASAS-PerSpA study were included. The proportion of patients with enthesitis identified by the indices was evaluated across the three diseases. Pairwise agreement between indices was computed using Cohen’s kappa. Results The prevalence rates of patients with at least one enthesitis according to the MEI, MASES, SPARCC index and LEI were 17.2%, 13.5%, 10.7%, and 8.3%, respectively. In axSpA, the indices that identified the most patients with enthesitis were the MEI and MASES (98.7% and 82.4%, respectively); in pSpA and PsA, the indices that identified the most patients with enthesitis were the MEI and SPARCC index (MEI: 100% and SPARCC: 84.6%; MEI: 97.3% and SPARCC: 77%, respectively). In the total population, the MASES vs. MEI showed the strongest agreement (absolute agreement 96.3%; kappa: 0.86); similar results were obtained in axSpA patients (97.3%; 0.90). In pSpA and PsA patients, the SPARCC vs. MEI (97.2%; 0.90 and 95.4%; 0.83, respectively) showed the strongest agreement. Conclusions These results suggest that the prevalence of patients with enthesitis across SpA subtypes differs depending on the disease and the index used. The MEI and MASES appeared best for assessing enthesis in SpA and axSpA, while the MEI and SPARCC index appeared best for assessing enthesitis in pSpA and PsA. |
| first_indexed | 2024-03-13T06:08:58Z |
| format | Article |
| id | doaj.art-00bd9228c7ab4db8af44cb80356f6d1c |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-03-13T06:08:58Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-00bd9228c7ab4db8af44cb80356f6d1c2023-06-11T11:21:25ZengBMCArthritis Research & Therapy1478-63622023-06-0125111010.1186/s13075-023-03080-0Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA dataRaquel Ena María Granados0M. Lourdes Ladehesa-Pineda1M. Ángeles Puche-Larrubia2Alejandro Escudero-Contreras3Maxime Dougados4Eduardo Collantes-Estevez5Clementina López-Medina6Rheumatology Department, Reina Sofia University HospitalRheumatology Department, Reina Sofia University HospitalRheumatology Department, Reina Sofia University HospitalRheumatology Department, Reina Sofia University HospitalRheumatology Department, Cochin Hospital, AP-HP, Paris, FR. INSERM U1153, CRESS, Université Paris-CitéRheumatology Department, Reina Sofia University HospitalRheumatology Department, Reina Sofia University HospitalAbstract Background In axial spondyloarthritis (axSpA), peripheral SpA (pSpA) and psoriatic arthritis (PsA), enthesitis is a hallmark clinical feature that can be assessed by the SPARCC index, LEI, MASES and MEI. These indices evaluate different locations, which may identify different numbers of patients with enthesitis among SpA subtypes. Thus, the aim of this study was to evaluate whether the proportion of patients with at least one enthesitis across these three most prevalent SpA subtypes differs according to the index used and to evaluate the level of agreement among indices in detecting patients with enthesitis. Methods A total of 4185 patients (2719 axSpA, 433 pSpA and 1033 PsA) from the international and cross-sectional ASAS-PerSpA study were included. The proportion of patients with enthesitis identified by the indices was evaluated across the three diseases. Pairwise agreement between indices was computed using Cohen’s kappa. Results The prevalence rates of patients with at least one enthesitis according to the MEI, MASES, SPARCC index and LEI were 17.2%, 13.5%, 10.7%, and 8.3%, respectively. In axSpA, the indices that identified the most patients with enthesitis were the MEI and MASES (98.7% and 82.4%, respectively); in pSpA and PsA, the indices that identified the most patients with enthesitis were the MEI and SPARCC index (MEI: 100% and SPARCC: 84.6%; MEI: 97.3% and SPARCC: 77%, respectively). In the total population, the MASES vs. MEI showed the strongest agreement (absolute agreement 96.3%; kappa: 0.86); similar results were obtained in axSpA patients (97.3%; 0.90). In pSpA and PsA patients, the SPARCC vs. MEI (97.2%; 0.90 and 95.4%; 0.83, respectively) showed the strongest agreement. Conclusions These results suggest that the prevalence of patients with enthesitis across SpA subtypes differs depending on the disease and the index used. The MEI and MASES appeared best for assessing enthesis in SpA and axSpA, while the MEI and SPARCC index appeared best for assessing enthesitis in pSpA and PsA.https://doi.org/10.1186/s13075-023-03080-0EnthesitisIndicesSpondyloarthritisPsoriatic arthritis |
| spellingShingle | Raquel Ena María Granados M. Lourdes Ladehesa-Pineda M. Ángeles Puche-Larrubia Alejandro Escudero-Contreras Maxime Dougados Eduardo Collantes-Estevez Clementina López-Medina Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data Arthritis Research & Therapy Enthesitis Indices Spondyloarthritis Psoriatic arthritis |
| title | Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data |
| title_full | Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data |
| title_fullStr | Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data |
| title_full_unstemmed | Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data |
| title_short | Enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis: ASAS-PerSpA data |
| title_sort | enthesitis indices identify different patients with this characteristic in axial and peripheral spondyloarthritis and also in psoriatic arthritis asas perspa data |
| topic | Enthesitis Indices Spondyloarthritis Psoriatic arthritis |
| url | https://doi.org/10.1186/s13075-023-03080-0 |
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