A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment

A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment

Traumatic brain injury (TBI) is a major worldwide neurological disorder with no neuroprotective treatment available. Three-dimensional (3D) in vitro models of brain contusion serving as a screening platform for drug testing are lacking. Here we developed a new in vitro model of brain contusion on or...

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Bibliographic Details
Main Authors: Francesca Pischiutta, Helena Cavaleiro, Enrico Caruso, Francesca Tribuzio, Noemi Di Marzo, Federico Moro, Firas Kobeissy, Kevin K. Wang, António J. Salgado, Elisa R. Zanier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
traumatic brain injury
3D in vitro model
organotypic cortical brain slices
mesenchymal stromal cells
secretome
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1217987/full

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