Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11

Upregulating miR-181b promotes ferroptosis in osteoarthritic chondrocytes by inhibiting SLC7A11

Abstract Background Osteoarthritis (OA) is a common disease with a complex pathology. This study aimed to investigate the correlation between the aberrant upregulation of miR-181b and ferroptosis in chondrocytes during the progression of OA. Methods An OA cell model was constructed with erastin. Fer...

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Bibliographic Details
Main Authors: Dexin Wang, Yu Fang, Liang Lin, Wensuo Long, Lei Wang, Liwei Yu, Huaiming Deng, Dan Wang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
Chondrocytes
Ferroptosis
miR-181b-5p
SLC7A11
Online Access:https://doi.org/10.1186/s12891-023-07003-7

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