Protein SUMOylation modification and its associations with disease
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and progression of various...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2017-01-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170167 |
| _version_ | 1819263084185780224 |
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| author | Yanfang Yang Yu He Xixi Wang Ziwei liang Gu He Peng Zhang Hongxia Zhu Ningzhi Xu Shufang Liang |
| author_facet | Yanfang Yang Yu He Xixi Wang Ziwei liang Gu He Peng Zhang Hongxia Zhu Ningzhi Xu Shufang Liang |
| author_sort | Yanfang Yang |
| collection | DOAJ |
| description | SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and progression of various diseases. Herein, we summarize and discuss the signal crosstalk between SUMOylation and ubiquitination of proteins, protein SUMOylation relations with several diseases, and the identification approaches for SUMOylation site. With the continuous development of bioinformatics and mass spectrometry, several accurate and high-throughput methods have been implemented to explore small ubiquitin-like modifier-modified substrates and sites, which is helpful for deciphering protein SUMOylation-mediated molecular mechanisms of disease. |
| first_indexed | 2024-12-23T20:07:58Z |
| format | Article |
| id | doaj.art-00c1f9d2d7a746b3b1076b6fff38c6a8 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-12-23T20:07:58Z |
| publishDate | 2017-01-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-00c1f9d2d7a746b3b1076b6fff38c6a82022-12-21T17:32:53ZengThe Royal SocietyOpen Biology2046-24412017-01-0171010.1098/rsob.170167170167Protein SUMOylation modification and its associations with diseaseYanfang YangYu HeXixi WangZiwei liangGu HePeng ZhangHongxia ZhuNingzhi XuShufang LiangSUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and progression of various diseases. Herein, we summarize and discuss the signal crosstalk between SUMOylation and ubiquitination of proteins, protein SUMOylation relations with several diseases, and the identification approaches for SUMOylation site. With the continuous development of bioinformatics and mass spectrometry, several accurate and high-throughput methods have been implemented to explore small ubiquitin-like modifier-modified substrates and sites, which is helpful for deciphering protein SUMOylation-mediated molecular mechanisms of disease.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170167sumoylationsumo pathwaydesumoylationdisease |
| spellingShingle | Yanfang Yang Yu He Xixi Wang Ziwei liang Gu He Peng Zhang Hongxia Zhu Ningzhi Xu Shufang Liang Protein SUMOylation modification and its associations with disease Open Biology sumoylation sumo pathway desumoylation disease |
| title | Protein SUMOylation modification and its associations with disease |
| title_full | Protein SUMOylation modification and its associations with disease |
| title_fullStr | Protein SUMOylation modification and its associations with disease |
| title_full_unstemmed | Protein SUMOylation modification and its associations with disease |
| title_short | Protein SUMOylation modification and its associations with disease |
| title_sort | protein sumoylation modification and its associations with disease |
| topic | sumoylation sumo pathway desumoylation disease |
| url | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170167 |
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